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=== Pharmacology === | === Pharmacology === | ||
The active ingredients of the Amanita muscaria are ibotenic acid, muscimol, and muscarine the highest concentration of which is in the yellow tissue of the cap immediately below the skin<ref>United Nations, Amanita muscaria : present understanding of its chemistry Accessed on 18th Jun 2022 via<nowiki/>https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1970-01-01_4_page005.html</ref>. The first two ingredients act on the nervous system as GABAA agonists within thirty minutes to two hours after ingestion, causing dizziness, lack of coordination, delirium, spasms, and muscular cramps. These symptoms are temporary and subside within four to twenty-four hours. There is some evidence to suggest that the reported lilliputian hallucinations mimic Z-drug side effects<ref>Tsai MJ, Huang YB, Wu PC. A novel clinical pattern of visual hallucination after zolpidem use. J Toxicol Clin Toxicol. 2003;41:869–72.</ref><ref>Coleman DE, Ota K. Hallucinations with zolpidem and fluoxetine in an impaired driver. J Forensic Sci. 2004;49:392–3.</ref><ref>Kito S, Koga Y. Visual hallucinations and amnesia associated with zolpidem triggered by fluvoxamine: A possible interaction. Int Psychogeriatr. 2006;18:749–51.</ref><ref>Elko CJ, Burgess JL, Robertson WO. Zolpidem-associated hallucinations and serotonin reuptake inhibition: A possible interaction. J Toxicol Clin Toxicol. 1998;36:195–203.</ref><ref>'''Zolpidem-induced Hallucinations''': A Brief Case Report from the Indian Subcontinent. Gurvinder Pal Singh and Neeraj Loona. Indian J Psychol Med. 2013 Apr-Jun; 35(2): 212–213. doi: 10.4103/0253-7176.116260</ref>. | [[File:Lilliputian hallucinations.jpg|alt=Lilliputian hallucinations|thumb|'''Figure 3'''. Lilliputian hallucinations]] | ||
The active ingredients of the Amanita muscaria are ibotenic acid, muscimol, and muscarine the highest concentration of which is in the yellow tissue of the cap immediately below the skin<ref>United Nations, Amanita muscaria : present understanding of its chemistry Accessed on 18th Jun 2022 via<nowiki/>https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1970-01-01_4_page005.html</ref>. The first two ingredients act on the nervous system as GABAA agonists within thirty minutes to two hours after ingestion, causing dizziness, lack of coordination, delirium, spasms, and muscular cramps. These symptoms are temporary and subside within four to twenty-four hours. There is some evidence to suggest that the reported lilliputian hallucinations (see '''Figure 3''') mimic Z-drug side effects<ref>Tsai MJ, Huang YB, Wu PC. A novel clinical pattern of visual hallucination after zolpidem use. J Toxicol Clin Toxicol. 2003;41:869–72.</ref><ref>Coleman DE, Ota K. Hallucinations with zolpidem and fluoxetine in an impaired driver. J Forensic Sci. 2004;49:392–3.</ref><ref>Kito S, Koga Y. Visual hallucinations and amnesia associated with zolpidem triggered by fluvoxamine: A possible interaction. Int Psychogeriatr. 2006;18:749–51.</ref><ref>Elko CJ, Burgess JL, Robertson WO. Zolpidem-associated hallucinations and serotonin reuptake inhibition: A possible interaction. J Toxicol Clin Toxicol. 1998;36:195–203.</ref><ref>'''Zolpidem-induced Hallucinations''': A Brief Case Report from the Indian Subcontinent. Gurvinder Pal Singh and Neeraj Loona. Indian J Psychol Med. 2013 Apr-Jun; 35(2): 212–213. doi: 10.4103/0253-7176.116260</ref>. | |||
==== Toxicity ==== | ==== Toxicity ==== |