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MDMA: Difference between revisions
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==== MDMA Comedown ==== | ==== MDMA Comedown ==== | ||
There is a wide amount of anecdotal evidence and some scientific evidence<ref>'''Safety pharmacology of acute MDMA administration in healthy subjects.''' J Psychopharmacol 31: 576–588. Vizeli P, Liechti ME. (2017) Accessed on 20 Nov 2023 via https://pubmed.ncbi.nlm.nih.gov/28443695/</ref><ref>'''Gender differences in the subjective effects of MDMA.''' Liechti ME, Gamma A, Vollenweider FX. (2001) Psychopharmacology 154: 161–168. Accessed on 20 Nov 2023: https://pubmed.ncbi.nlm.nih.gov/11314678/</ref> to suggest that after using MDMA there is an emotional comedown reported colloquially as "''Blue Mondays''". However, a recent, low powered study found that there was little evidence for this<ref>'''Debunking the myth of 'Blue Mondays': No evidence of affect drop after taking clinical MDMA.''' J Psychopharmacol. 2022 Mar;36(3):360-367. doi: 10.1177/02698811211055809. Epub 2021 Dec 13. . Ben Sessa, Jacob S Aday, Steve O'Brien, H Valerie Curran, Fiona Measham, Laurie Higbed, David J Nutt. https://pubmed.ncbi.nlm.nih.gov/34894842/</ref>. | There is a wide amount of anecdotal evidence and some scientific evidence<ref>'''Safety pharmacology of acute MDMA administration in healthy subjects.''' J Psychopharmacol 31: 576–588. Vizeli P, Liechti ME. (2017) Accessed on 20 Nov 2023 via https://pubmed.ncbi.nlm.nih.gov/28443695/</ref><ref>'''Gender differences in the subjective effects of MDMA.''' Liechti ME, Gamma A, Vollenweider FX. (2001) Psychopharmacology 154: 161–168. Accessed on 20 Nov 2023: https://pubmed.ncbi.nlm.nih.gov/11314678/</ref> to suggest that after using MDMA there is an emotional comedown potentially due to prolactin release<ref>'''Ecstasy (MDMA) mimics the post-orgasmic state: impairment of sexual drive and function during acute MDMA-effects may be due to increased prolactin secretion.''' Passie T, Hartmann U, Schneider U, Emrich HM, Krüger TH. Med Hypotheses. 2005;64(5):899-903. doi: 10.1016/j.mehy.2004.11.044. PMID: 15780482.</ref> reported colloquially as "''Blue Mondays''". However, a recent, low powered study found that there was little evidence for this<ref>'''Debunking the myth of 'Blue Mondays': No evidence of affect drop after taking clinical MDMA.''' J Psychopharmacol. 2022 Mar;36(3):360-367. doi: 10.1177/02698811211055809. Epub 2021 Dec 13. . Ben Sessa, Jacob S Aday, Steve O'Brien, H Valerie Curran, Fiona Measham, Laurie Higbed, David J Nutt. https://pubmed.ncbi.nlm.nih.gov/34894842/</ref>. | ||
'''References''' | '''References''' | ||