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MDMA: Difference between revisions
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==== Neurophysiology ==== | ==== Neurophysiology ==== | ||
The change in neural activity coupled with the release of the neurochmicals / neuromodulators above cause a reduction in communication between the medial temporal lobe and the medial prefrontal cortex, which play roles in emotional control. Collectively, these effects work contrary to the patterns observed in individuals experiencing anxiety.<ref>'''3,4-Methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats.''' Hake, H. S. et al. ''Physiol. Behav.'' 199, 343–350 (2019). | The change in neural activity coupled with the release of the neurochmicals / neuromodulators above cause a reduction in communication between the medial temporal lobe and the medial prefrontal cortex, which play roles in emotional control. Collectively, these effects work contrary to the patterns observed in individuals experiencing anxiety.<ref>'''3,4-Methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats.''' Hake, H. S. et al. ''Physiol. Behav.'' 199, 343–350 (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557441/</ref><ref>'''Oxytocin-dependent reopening of a social reward learning critical period with MDMA.''' Nardou, R. et al. ''Nature'' 569, 116–120 (2019). https://doi.org/10.1038%2Fs41586-019-1075-9</ref> | ||
==== Toxicity ==== | ==== Toxicity ==== | ||