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MDMA: Difference between revisions
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== Adverse Effects == | == Adverse Effects == | ||
MDMA at high doses can be neurotoxic, in addition, due to its amphetamine component MDMA can increase blood pressure, meaning its use is contraindicated in people with preexisting hypertension. | |||
==== Toxicity ==== | ==== Toxicity ==== | ||
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==== MDMA Comedown ==== | ==== MDMA Comedown ==== | ||
There is a wide amount of anecdotal evidence and some scientific evidence<ref>'''Safety pharmacology of acute MDMA administration in healthy subjects.''' J Psychopharmacol 31: 576–588. Vizeli P, Liechti ME. (2017) Accessed on 20 Nov 2023 via https://pubmed.ncbi.nlm.nih.gov/28443695/</ref><ref>'''Gender differences in the subjective effects of MDMA.''' Liechti ME, Gamma A, Vollenweider FX. (2001) Psychopharmacology 154: 161–168. Accessed on 20 Nov 2023: https://pubmed.ncbi.nlm.nih.gov/11314678/</ref> to suggest that after using MDMA there is an emotional comedown potentially due to prolactin release<ref>'''Ecstasy (MDMA) mimics the post-orgasmic state: impairment of sexual drive and function during acute MDMA-effects may be due to increased prolactin secretion.''' Passie T, Hartmann U, Schneider U, Emrich HM, Krüger TH. Med Hypotheses. 2005;64(5):899-903. doi: 10.1016/j.mehy.2004.11.044. PMID: 15780482.</ref> reported colloquially as "''Blue Mondays''". However, a recent, low powered study found that there was little evidence for this<ref>'''Debunking the myth of 'Blue Mondays': No evidence of affect drop after taking clinical MDMA.''' J Psychopharmacol. 2022 Mar;36(3):360-367. doi: 10.1177/02698811211055809. Epub 2021 Dec 13. . Ben Sessa, Jacob S Aday, Steve O'Brien, H Valerie Curran, Fiona Measham, Laurie Higbed, David J Nutt. https://pubmed.ncbi.nlm.nih.gov/34894842/</ref>. | There is a wide amount of anecdotal evidence and some scientific evidence<ref>'''Safety pharmacology of acute MDMA administration in healthy subjects.''' J Psychopharmacol 31: 576–588. Vizeli P, Liechti ME. (2017) Accessed on 20 Nov 2023 via https://pubmed.ncbi.nlm.nih.gov/28443695/</ref><ref>'''Gender differences in the subjective effects of MDMA.''' Liechti ME, Gamma A, Vollenweider FX. (2001) Psychopharmacology 154: 161–168. Accessed on 20 Nov 2023: https://pubmed.ncbi.nlm.nih.gov/11314678/</ref> to suggest that after using MDMA there is an emotional comedown potentially due to prolactin release<ref>'''Ecstasy (MDMA) mimics the post-orgasmic state: impairment of sexual drive and function during acute MDMA-effects may be due to increased prolactin secretion.''' Passie T, Hartmann U, Schneider U, Emrich HM, Krüger TH. Med Hypotheses. 2005;64(5):899-903. doi: 10.1016/j.mehy.2004.11.044. PMID: 15780482.</ref> reported colloquially as "''Blue Mondays''". However, a recent, low powered study found that there was little evidence for this<ref>'''Debunking the myth of 'Blue Mondays': No evidence of affect drop after taking clinical MDMA.''' J Psychopharmacol. 2022 Mar;36(3):360-367. doi: 10.1177/02698811211055809. Epub 2021 Dec 13. . Ben Sessa, Jacob S Aday, Steve O'Brien, H Valerie Curran, Fiona Measham, Laurie Higbed, David J Nutt. https://pubmed.ncbi.nlm.nih.gov/34894842/</ref>. | ||
==== MDMA Toxicity Protection ==== | |||
Some animal and human studies have suggested taking a range of supplements before MDMA administration to protect the user from MDMA induced neurotoxicity. | |||
* '''Alpha lipoic acid (ALA)''': 300 milligrams (mg) of ALA at the same time as MDMA, followed by 100 – 150 mg of ALA every 1-2 hours thereafter for the duration of the trip. (Conservative practitioners suggest a maximum dose of 2,400 mg of ALA in a 24-hour period.) | |||
* '''Acetyl-L carnitine (ALC)''': 500 mg of ALC three hours before taking MDMA, 500mg one hour after the MDMA, and 500 mg four hours later (five hours after the MDMA), for a total dose of 1,500 mg of ALC. (Conservative practitioners suggest a maximum dose of 2,500mg of ALC per 24-hour period.) | |||
* '''N-acetyl cysteine (NAC)''': 900 mg of NAC on an empty stomach, shortly before the MDMA and again at the end of the session. | |||
* '''Vitamin C''': 500 – 2,000 mg (half a gram – 2 grams) of sodium ascorbate every two hours the day of the MDMA session. (Sodium ascorbate is a form of vitamin C that’s less likely to cause an upset stomach than regular ascorbic acid.) Reduce the dose if loose stools occur. | |||
In addition, it is suggested that 5-HTP supplements can be used after the 5-HTP dose to replenish lost neurotransmitters, however, taking 5-HTP too soon after MDMA can cause a serious and potentially life-threatening condition known as serotonin syndrome. (The same goes for combining 5-HTP with SSRI antidepressants.) For that reason, it is recommend that people wait 48 hours after taking MDMA before starting a 5-HTP supplement. Dosage is around 100 to 400 mg daily for two weeks after taking MDMA, starting two days after the MDMA experience. | |||
'''References''' | '''References''' | ||