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MDMA: Difference between revisions
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==== Toxicity ==== | ==== Toxicity ==== | ||
It is possible that overusage of MDMA could lead to neurotoxicity via dopamine overload. However, a long term study has shown that there is little evidence of decreased cognitive performance in ecstasy users, save for poorer strategic-self-regulation, possibly reflecting increased impulsivity<ref>'''Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs.''' Addiction. Halpern JH, Sherwood AR, Hudson JI, Gruber S, Kozin D, Pope HG Jr. 2011 Apr;106(4):777-86. doi: 10.1111/j.1360-0443.2010.03252.x. Epub 2011 Feb 15. PMID: 21205042; PMCID: PMC3053129.</ref>. | |||
Co-administration of caffeine profoundly enhances the acute toxicity of MDMA in rats, as manifested by high core body temperature, tachycardia and increased mortality. In addition, co-administration of caffeine enhances the long-term serotonergic neurotoxicity induced by MDMA<ref>'''Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.''' Vanattou-Saïfoudine N, McNamara R, Harkin A. Br J Pharmacol. 2012 Nov;167(5):946-59. doi: 10.1111/j.1476-5381.2012.02065.x. PMID: 22671762; PMCID: PMC3492978.</ref>. | |||
== Effects == | == Effects == | ||