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MDMA: Difference between revisions
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[[File:MDMA.jpg|alt=Ecstasy|thumb|'''Figure 1.''' MDMA in pill form, aka Ecstasy]] | [[File:MDMA.jpg|alt=Ecstasy|thumb|'''Figure 1.''' MDMA in pill form, aka Ecstasy]] | ||
'''MDMA, commonly known as ecstasy or Molly, is a synthetic drug that induces both amphetamine-like stimulation and mild [[hallucinations]].''' MDMA has been shown to enhance [[Fear Memory Extinction|fear memory extinction]], modulate fear memory reconsolidation (possibly through an oxytocin-dependent mechanism), and bolster social behavior in animal models | '''MDMA, commonly known as ecstasy or Molly, is a synthetic drug that induces both amphetamine-like stimulation and mild [[hallucinations]].''' MDMA has been shown to enhance [[Fear Memory Extinction|fear memory extinction]], modulate fear memory reconsolidation (possibly through an oxytocin-dependent mechanism), and bolster social behavior in animal models. | ||
== Clinical Dosage == | == Clinical Dosage == | ||
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==== MDMA Comedown ==== | ==== MDMA Comedown ==== | ||
There is a wide amount of anecdotal evidence and some scientific evidence<ref>'''Safety pharmacology of acute MDMA administration in healthy subjects.''' J Psychopharmacol 31: 576–588. Vizeli P, Liechti ME. (2017) Accessed on 20 Nov 2023 via https://pubmed.ncbi.nlm.nih.gov/28443695/</ref><ref>'''Gender differences in the subjective effects of MDMA.''' Liechti ME, Gamma A, Vollenweider FX. (2001) Psychopharmacology 154: 161–168. Accessed on 20 Nov 2023: https://pubmed.ncbi.nlm.nih.gov/11314678/</ref> to suggest that after using MDMA there is an emotional comedown reported colloquially as "''Blue Mondays''". However, a recent, low powered study found that there was little evidence for this<ref>'''Debunking the myth of 'Blue Mondays': No evidence of affect drop after taking clinical MDMA.''' J Psychopharmacol. 2022 Mar;36(3):360-367. doi: 10.1177/02698811211055809. Epub 2021 Dec 13. . Ben Sessa, Jacob S Aday, Steve O'Brien, H Valerie Curran, Fiona Measham, Laurie Higbed, David J Nutt. https://pubmed.ncbi.nlm.nih.gov/34894842/</ref>. | There is a wide amount of anecdotal evidence and some scientific evidence<ref>'''Safety pharmacology of acute MDMA administration in healthy subjects.''' J Psychopharmacol 31: 576–588. Vizeli P, Liechti ME. (2017) Accessed on 20 Nov 2023 via https://pubmed.ncbi.nlm.nih.gov/28443695/</ref><ref>'''Gender differences in the subjective effects of MDMA.''' Liechti ME, Gamma A, Vollenweider FX. (2001) Psychopharmacology 154: 161–168. Accessed on 20 Nov 2023: https://pubmed.ncbi.nlm.nih.gov/11314678/</ref> to suggest that after using MDMA there is an emotional comedown reported colloquially as "''Blue Mondays''". However, a recent, low powered study found that there was little evidence for this<ref>'''Debunking the myth of 'Blue Mondays': No evidence of affect drop after taking clinical MDMA.''' J Psychopharmacol. 2022 Mar;36(3):360-367. doi: 10.1177/02698811211055809. Epub 2021 Dec 13. . Ben Sessa, Jacob S Aday, Steve O'Brien, H Valerie Curran, Fiona Measham, Laurie Higbed, David J Nutt. https://pubmed.ncbi.nlm.nih.gov/34894842/</ref>. | ||
== Co Administration == | |||
It is thought that the effects of MDMA might be further potentiated by administration with [[psilocybin]] termed a [[Hippie Flip|hippie flip]]. | |||
'''References''' | '''References''' | ||