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SSRI and psychedelics: Difference between revisions
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'''Pre-2023 it was a commonly held belief by healthcare practitioners that there was a theoretical interaction between [[psychedelics]] and SSRIs that may cause [[serotonin]] syndrome, a potentially fatal reaction.''' However, the serotonin theory of action of antidepressants<ref>'''“No convincing evidence”'''. BMJ 2022; 378 doi: <nowiki>https://doi.org/10.1136/bmj.o1808</nowiki> (Published 20 July 2022) BMJ 2022;378:o1808</ref> and psychedelics is now under debate and there is now some empirical data to suggest that there is a weak interaction<ref>'''Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use'''. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910</ref> or even no interaction<ref>'''Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication.''' Goodwin, G.M., Croal, M., Feifel, D. ''et al. Neuropsychopharmacol.'' (2023). https://www.nature.com/articles/s41386-023-01648-7</ref>. | '''Pre-2023 it was a commonly held belief by healthcare practitioners that there was a theoretical interaction between [[psychedelics]] and SSRIs that may cause [[serotonin]] syndrome, a potentially fatal reaction.''' However, the serotonin theory of action of antidepressants<ref>'''“No convincing evidence”'''. BMJ 2022; 378 doi: <nowiki>https://doi.org/10.1136/bmj.o1808</nowiki> (Published 20 July 2022) BMJ 2022;378:o1808</ref> and psychedelics is now under debate and there is now some empirical data to suggest that there is a weak interaction<ref>'''Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use'''. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910</ref> or even no interaction<ref>'''Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects.''' Clinical Pharmacology & TherapeuticsVolume 111, Issue 4 p. 886-895. Accessed via: https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2487</ref><ref>'''Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication.''' Goodwin, G.M., Croal, M., Feifel, D. ''et al. Neuropsychopharmacol.'' (2023). https://www.nature.com/articles/s41386-023-01648-7</ref>. | ||
=== SSRIs vs Psychedelics === | === SSRIs vs Psychedelics === | ||