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MADRS: Difference between revisions
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(Created page with "'''The Montgomery–Åsberg Depression Rating Scale (MADRS) is a widely used clinician‐rated rating in psychedelic clinical trials to measure depressive severity.''' MADRS is a 10-item clinician-administered scale that measures various symptoms of depression. Each item is scored on a 0-6 point scale, with the total score ranging from 0 to 60. Higher scores indicate more severe depressive symptoms. === Psychedelic Therapy and Depression === Psychedeli...") |
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'''The Montgomery–Åsberg Depression Rating Scale (MADRS) is a widely used clinician‐rated rating in [[Psychedelics|psychedelic]] clinical trials to measure depressive severity.''' MADRS is a 10-item clinician-administered scale | '''The Montgomery–Åsberg Depression Rating Scale (MADRS) is a widely used clinician‐rated rating in [[Psychedelics|psychedelic]] clinical trials to measure depressive severity.''' MADRS is a 10-item clinician-administered scale covering: | ||
* Apparent sadness | |||
* Reported sadness | |||
* Inner tension | |||
* Reduced sleep | |||
* Reduced appetite | |||
* Concentration difficulties | |||
* Lassitude | |||
* Inability to feel | |||
* Pessimistic thoughts | |||
* Suicidal thoughts | |||
Each item yields a score of 0 to 6; the overall score thus ranges from 0 to 60. One of the largest psychedlic (psilocybin) studies has found that a 2.5mg dose can lead to a 6.6 point reduction in MADRS score<ref>'''COMPASS Pathways announces positive topline results from groundbreaking phase IIb trial of investigational COMP360 psilocybin therapy for treatment-resistant depression.''' November 09, 2021. Accessed on 17th October 2023 via: https://ir.compasspathways.com/news-releases/news-release-details/compass-pathways-announces-positive-topline-results</ref>. | |||
=== Psychedelic Therapy and Depression === | === Psychedelic Therapy and Depression === | ||
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=== Limitations: === | === Limitations: === | ||
While the MADRS is a valuable tool, it's essential to combine its findings with other clinical observations and potentially other assessment tools. This is especially true in psychedelic therapy, where profound existential and spiritual experiences might not be fully captured by traditional depression rating scales. | While the MADRS is a valuable tool, it's essential to combine its findings with other clinical observations and potentially other assessment tools. This is especially true in psychedelic therapy, where profound existential and spiritual experiences might not be fully captured by traditional depression rating scales. | ||
'''References''' | |||