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Psychedelics: Difference between revisions
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The medical definition of ''microdosing'' is a dose given which is ''sub therapeutic'', i.e. it is the dose doctors recognise as having no discernible effect. However, many claim, mainly via online survey studies, that very low doses of LSD, taken at 3–4-day intervals, improve mood and cognitive function<ref>'''Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting.''' Prochazkova, L., Lippelt, D.P., Colzato, L.S. ''et al.'' ''Psychopharmacology'' 235, 3401–3413 (2018). <nowiki>https://doi.org/10.1007/s00213-018-5049-7</nowiki></ref>. | The medical definition of ''microdosing'' is a dose given which is ''sub therapeutic'', i.e. it is the dose doctors recognise as having no discernible effect. However, many claim, mainly via online survey studies, that very low doses of LSD, taken at 3–4-day intervals, improve mood and cognitive function<ref>'''Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting.''' Prochazkova, L., Lippelt, D.P., Colzato, L.S. ''et al.'' ''Psychopharmacology'' 235, 3401–3413 (2018). <nowiki>https://doi.org/10.1007/s00213-018-5049-7</nowiki></ref>. | ||
In controlled studies, which in mental health are the gold standard, (see [[Referencing|critical appraisal]]) the placebo effect is excluded. In all of these studies microdosing has been shown to have no effect<ref>'''Repeated low doses of LSD in healthy adults: A placebo-controlled, dose–response study''' Harriet de Wit,Hanna M. Molla,Anya Bershad,Michael Bremmer,Royce Lee First published: 01 February 2022 <nowiki>https://doi.org/10.1111/adb.13143</nowiki>https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.13143</ref> and even in some have shown negative effects such as neuroticism<ref>'''A Systematic Study of Microdosing'''. Richard J. Stevenson, Macquarie University, Sydney, Australia. 10.1371/journal.pone.0211023</ref>. It has been suggested that this is because the experience of the ''trip'' is more important than the underlying chemical-electrical mechanisms<ref>'''The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects''': David B. Yaden and Roland R. Griffiths* ACS Pharmacol. Transl. Sci. 2021, 4, 2, 568–572. Publication Date:December 10, 2020. <nowiki>https://doi.org/10.1021/acsptsci.0c00194</nowiki></ref> (see '''Figure 6''') . By propagating the myth that microdosing does have an effect may cause people from not accessing the correct dose and getting the actual benefit from the medicine. | In controlled studies, which in mental health are the gold standard, (see [[Referencing|critical appraisal]]) the placebo effect is excluded. In all of these studies microdosing has been shown to have no effect<ref>'''Repeated low doses of LSD in healthy adults: A placebo-controlled, dose–response study''' Harriet de Wit,Hanna M. Molla,Anya Bershad,Michael Bremmer,Royce Lee First published: 01 February 2022 <nowiki>https://doi.org/10.1111/adb.13143</nowiki>https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.13143</ref> and even in some have shown negative effects such as neuroticism<ref>'''A Systematic Study of Microdosing'''. Richard J. Stevenson, Macquarie University, Sydney, Australia. 10.1371/journal.pone.0211023</ref> or even the potential to cause valvular heart disease<ref>'''The risk of chronic psychedelic and MDMA microdosing for valvular heart disease'''. Michael Tagen, Daniel Mantuani, Journal of Psychopharmacology, Volume 37, Issue 9. Accessed on 4 October 2023 via: <nowiki>https://journals.sagepub.com/doi/10.1177/02698811231190865</nowiki></ref>. It has been suggested that this is because the experience of the ''trip'' is more important than the underlying chemical-electrical mechanisms<ref>'''The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects''': David B. Yaden and Roland R. Griffiths* ACS Pharmacol. Transl. Sci. 2021, 4, 2, 568–572. Publication Date:December 10, 2020. <nowiki>https://doi.org/10.1021/acsptsci.0c00194</nowiki></ref> (see '''Figure 6''') . By propagating the myth that microdosing does have an effect may cause people from not accessing the correct dose and getting the actual benefit from the medicine. | ||
== Oneirogens == | == Oneirogens == | ||