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Psilocybin: Difference between revisions
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[[File:Psilocybin depression treatment.png|thumb|'''Figure 2'''. Depression symptom reduction from placebo, low dose and therapeutic dose of psilocybin.]] | [[File:Psilocybin depression treatment.png|thumb|'''Figure 2'''. Depression symptom reduction from placebo, low dose and therapeutic dose of psilocybin.]] | ||
The dose to cure depression has seen a dose dependency 25mg is a better dose than lower doses such 10mg or microdosing<ref>'''Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression'''. Guy M. Goodwin. First published November 3, 2022. N Engl J Med 2022; 387:1637-1648. DOI: 10.1056/NEJMoa2206443. Accessed on 5th November via <nowiki>https://www.nejm.org/doi/full/10.1056/NEJMoa2206443</nowiki></ref> (see '''Figure 2'''). This equates to 10–20µg l–1 psilocin in plasma, which corresponds to ~60% occupancy of serotonin 2A (5-HT2A) receptors in the neocortex of humans.<ref>'''Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels'''. MK Madsen Neuropsychopharmacology, first published 2019. Accessed on 5th November 2022 via https://www.nature.com/articles/s41386-019-0324-9</ref> Psychological effects start around 10–40 min after ingestion and last for 2–6 h. | The dose to cure depression has seen a dose dependency 25mg is a better dose than lower doses such 10mg or microdosing<ref>'''Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression'''. Guy M. Goodwin. First published November 3, 2022. N Engl J Med 2022; 387:1637-1648. DOI: 10.1056/NEJMoa2206443. Accessed on 5th November via <nowiki>https://www.nejm.org/doi/full/10.1056/NEJMoa2206443</nowiki></ref> (see '''Figure 2'''). This equates to 10–20µg l–1 psilocin in plasma, which corresponds to ~60% occupancy of serotonin 2A (5-HT2A) receptors in the neocortex of humans.<ref>'''Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels'''. MK Madsen Neuropsychopharmacology, first published 2019. Accessed on 5th November 2022 via https://www.nature.com/articles/s41386-019-0324-9</ref> Psychological effects start around 10–40 min after ingestion and last for 2–6 h. | ||
==== Psychedelic Experience ==== | |||
During clinical studies it is common for those carrying out the trial to match the dynamic of the psychedelic experience (trip) with a musical playlist which includes: | |||
# '''Low Vocalization (for the onset)''' - commonly classical, low volume (first 45 minutes) | |||
# '''Peak Emotion''' - percussion, higher volumes (45-90 minutes) | |||
# '''Comedown''' - Can be choral, melodic, commonly have female voices, nature sounds or mimics the "outside world" (after 90 mins) | |||
'''Reference''' | '''Reference''' | ||
<references /> | <references /> | ||