SSRI and psychedelics: Difference between revisions

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-It is thought that if psychedelics are used with SSRIs such as fluoxetine this may lead to [[serotonin]] syndrome and a decrease in subjective [[Psychedelics|psychedelic]] effects. However, this is theoretical and there is no empirical data on the interaction between psychedelics and antidepressants although it is thought to be more pronounced with people taking NMDA. Recently, the serotonin theory of depression has been cast into doubt by large studies<ref>“No convincing evidence”. BMJ 2022; 378 doi: <nowiki>https://doi.org/10.1136/bmj.o1808</nowiki> (Published 20 July 2022) BMJ 2022;378:o1808</ref>, further disproving this theory.
+Theoretically, when SSRIs such as fluoxetine are taken at the same time as a psychedelic, [[serotonin]] syndrome, a potentially fatal reaction can occur may occur. However, although this reaction is theoretically possible there is no confirming empirical data. Recently, the serotonin theory of depression has been cast into doubt by large studies<ref>'''“No convincing evidence”'''. BMJ 2022; 378 doi: <nowiki>https://doi.org/10.1136/bmj.o1808</nowiki> (Published 20 July 2022) BMJ 2022;378:o1808</ref>, further disproving this theory.
+However, SSRI and SNRIs appear to weaken [[psilocybin]] drug effects relative to a non-serotonergic antidepressant. This dampening effect may last as long as 3 months following antidepressant discontinuation<ref>'''Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use'''. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910</ref>.
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 '''References'''

SSRI and psychedelics (view source)

Revision as of 07:54, 14 June 2023

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