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=== Pharmacology === | === Pharmacology === | ||
[[File:Lilliputian hallucinations.jpg|alt=Lilliputian hallucinations|thumb|'''Figure 3'''. Lilliputian hallucinations]] | [[File:Lilliputian hallucinations.jpg|alt=Lilliputian hallucinations|thumb|'''Figure 3'''. Lilliputian hallucinations]] | ||
The active ingredients of the Amanita muscaria are ibotenic acid, muscimol, and muscarine the highest concentration of which is in the yellow tissue of the cap immediately below the skin<ref>United Nations, Amanita muscaria : present understanding of its chemistry Accessed on 18th Jun 2022 via<nowiki/>https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1970-01-01_4_page005.html</ref>. The first two ingredients act on the nervous system as GABAA agonists within thirty minutes to two hours after ingestion, causing dizziness, lack of coordination, delirium, spasms, and muscular cramps. These symptoms are temporary and subside within four to twenty-four hours. There is some evidence to suggest that the reported lilliputian hallucinations (see '''Figure 3''') mimic Z-drug side effects<ref>Tsai MJ, Huang YB, Wu PC. A novel clinical pattern of visual hallucination after zolpidem use. J Toxicol Clin Toxicol. 2003;41:869–72.</ref><ref>Coleman DE, Ota K. Hallucinations with zolpidem and fluoxetine in an impaired driver. J Forensic Sci. 2004;49:392–3.</ref><ref>Kito S, Koga Y. Visual hallucinations and amnesia associated with zolpidem triggered by fluvoxamine: A possible interaction. Int Psychogeriatr. 2006;18:749–51.</ref><ref>Elko CJ, Burgess JL, Robertson WO. Zolpidem-associated hallucinations and serotonin reuptake inhibition: A possible interaction. J Toxicol Clin Toxicol. 1998;36:195–203.</ref><ref>'''Zolpidem-induced Hallucinations''': A Brief Case Report from the Indian Subcontinent. Gurvinder Pal Singh and Neeraj Loona. Indian J Psychol Med. 2013 Apr-Jun; 35(2): 212–213. doi: 10.4103/0253-7176.116260</ref>. | The active ingredients of the Amanita muscaria are ibotenic acid, muscimol, and muscarine the highest concentration of which is in the yellow tissue of the cap immediately below the skin<ref>United Nations, Amanita muscaria : present understanding of its chemistry Accessed on 18th Jun 2022 via<nowiki/>https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1970-01-01_4_page005.html</ref>. The first two ingredients act on the nervous system as GABAA agonists within thirty minutes to two hours after ingestion, causing dizziness, lack of coordination, delirium, spasms, and muscular cramps. These symptoms are temporary and subside within four to twenty-four hours. There is some evidence to suggest that the reported lilliputian [[hallucinations]] (see '''Figure 3''') mimic Z-drug side effects<ref>Tsai MJ, Huang YB, Wu PC. A novel clinical pattern of visual hallucination after zolpidem use. J Toxicol Clin Toxicol. 2003;41:869–72.</ref><ref>Coleman DE, Ota K. Hallucinations with zolpidem and fluoxetine in an impaired driver. J Forensic Sci. 2004;49:392–3.</ref><ref>Kito S, Koga Y. Visual hallucinations and amnesia associated with zolpidem triggered by fluvoxamine: A possible interaction. Int Psychogeriatr. 2006;18:749–51.</ref><ref>Elko CJ, Burgess JL, Robertson WO. Zolpidem-associated hallucinations and serotonin reuptake inhibition: A possible interaction. J Toxicol Clin Toxicol. 1998;36:195–203.</ref><ref>'''Zolpidem-induced Hallucinations''': A Brief Case Report from the Indian Subcontinent. Gurvinder Pal Singh and Neeraj Loona. Indian J Psychol Med. 2013 Apr-Jun; 35(2): 212–213. doi: 10.4103/0253-7176.116260</ref>. | ||
==== Toxicity ==== | ==== Toxicity ==== | ||
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== Effect == | == Effect == | ||
Lilliputian hallucinations concern hallucinated human, animal or fantasy entities of minute size. They have been reported anecdotally for millennia however, in the 1960s while the number of medical publications on lilliputian hallucinations had dwindled, young people became fascinated with records of ancient shamanic traditions and expressed a longing to encounter the sentient, discarnate beings described after the use of [[psychedelics]]<ref name=":1">The Invisible Landscape: Mind, Hallucinogens, and the I Ching, Terence Mckenna, published in 1993, ISBN 0062506358</ref>. | Lilliputian [[hallucinations]] concern hallucinated human, animal or fantasy entities of minute size. They have been reported anecdotally for millennia however, in the 1960s while the number of medical publications on lilliputian hallucinations had dwindled, young people became fascinated with records of ancient shamanic traditions and expressed a longing to encounter the sentient, discarnate beings described after the use of [[psychedelics]]<ref name=":1">The Invisible Landscape: Mind, Hallucinogens, and the I Ching, Terence Mckenna, published in 1993, ISBN 0062506358</ref>. | ||
A modern retrospective analysis of scientific data shows descriptions of the ‘fly-agaric men’ and ‘amanita girls’ evoked by the mushroom Amanita muscaria show striking similarities to Leroy’s lilliputian hallucinations<ref>The Encyclopedia of Psychoactive Substances, Richard Rudgley, St. Martin's Publishing Group, 2014, ISBN: 1466886005</ref>. The same holds true for Chinese descriptions of xiao ren ren (‘lots of little people’), prompted by the consumption of undercooked blue-staining boletes<ref>Xiao Ren Ren : The “Little People” of Yunnan, November 2008Economic Botany 62(3):540-544, DOI:10.1007/s12231-008-9049-0</ref>. | A modern retrospective analysis of scientific data shows descriptions of the ‘fly-agaric men’ and ‘amanita girls’ evoked by the mushroom Amanita muscaria show striking similarities to Leroy’s lilliputian hallucinations<ref>The Encyclopedia of Psychoactive Substances, Richard Rudgley, St. Martin's Publishing Group, 2014, ISBN: 1466886005</ref>. The same holds true for Chinese descriptions of xiao ren ren (‘lots of little people’), prompted by the consumption of undercooked blue-staining boletes<ref>Xiao Ren Ren : The “Little People” of Yunnan, November 2008Economic Botany 62(3):540-544, DOI:10.1007/s12231-008-9049-0</ref>. |