2,736
edits
mNo edit summary |
|||
Line 57: | Line 57: | ||
=== Medicinal Chemistry === | === Medicinal Chemistry === | ||
All psychedelics are chemically unique and but can be catergorised into four main main types (see | All psychedelics are chemically unique and but can be catergorised into four main main types (see '''Figure 2'''). There are three main families of chemical compounds: [[tryptamines]], phenethylamines, or lysergamides and many tend to act via serotonin 2A receptor agonism which plays a key role in regulation of cortical function. Serotonin antagonism has been proposed as the mechanism for the subjective and biological effects of classical psychedelics as these effects are blocked after administering 5HT2AR antagonists such as ketanserin<ref>Preller KH, Herdener M, Pokorny T, Planzer A, Kraehenmann R, Stämpfli P, et al. The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation. Curr Biol. 2017 Feb;27(3):451–7.</ref><ref>Ly C, Greb AC, Cameron LP, Wong JM, Barragan EV, Wilson PC, et al. Psychedelics Promote Structural and Functional Neural Plasticity. Cell Rep. 2018 Jun 12;23(11):3170–82.</ref>. | ||
=== Duration of psychedelic state === | === Duration of psychedelic state === | ||
Line 75: | Line 75: | ||
* Those taking citalopram (Cipramil), dapoxetine (Priligy), escita<nowiki/>lopram (Cipralex), fluoxetine (Prozac or Oxactin) or other SSRIs. | * Those taking citalopram (Cipramil), dapoxetine (Priligy), escita<nowiki/>lopram (Cipralex), fluoxetine (Prozac or Oxactin) or other SSRIs. | ||
* People taking '''olanzapine''' (an atypical antipsychotic) as there is some evidence to suggest it can [[Trip Terminator|''terminate'' a trip]]<ref>'''Olanzapine as the ideal “trip terminator”?''' Giuseppe Valeriani, Ornella Corazza, Francesco Saverio Bersani. First published: 28 July 2015 <nowiki>https://doi.org/10.1002/hup.2431</nowiki>. Accessed via: <nowiki>https://onlinelibrary.wiley.com/doi/10.1002/hup.2431</nowiki></ref>. | * People taking '''olanzapine''' (an atypical antipsychotic) as there is some evidence to suggest it can [[Trip Terminator|''terminate'' a trip]]<ref>'''Olanzapine as the ideal “trip terminator”?''' Giuseppe Valeriani, Ornella Corazza, Francesco Saverio Bersani. First published: 28 July 2015 <nowiki>https://doi.org/10.1002/hup.2431</nowiki>. Accessed via: <nowiki>https://onlinelibrary.wiley.com/doi/10.1002/hup.2431</nowiki></ref>. | ||
* Presence of high degrees of '''[[Psychedelic Anxiety Syndrome]]'''. | |||
* Presence or history of '''psychosis'''; | * Presence or history of '''psychosis'''; | ||
* Presence or history of mania or '''bipolar disorder'''; | * Presence or history of mania or '''bipolar disorder'''; |