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The mind is a [[Neurochemistry|neurochemical]] machine it has so many inputs it evolved the subconscious to stop too much noise overwhelming the system. The word Psychedelic means mind-manifesting, i.e. it is taking some of these subconscious inputs and opening it up to the conscious mind. They work like a switch, once present in the system they switch of the inhibitory system and systems become conscious. The effect is that millions of years of heuristics are opened up. Only those which were promoted to the conscious mind were accessible to you, now you can see what is under the hood. However, as we have a limited awareness i.e. processing power it is different to normal consciousness as all of the inputs which had been subdued are now switch on and you are only built to pay attention to one or two things at one time. So the experience is often incapacitating and thus makes us vulnerable. To deal with this the brain tries to find patterns and groups concepts into "icons", metaphorical symbols, which are being seen from a far. Many of these icons can be archetypal of general human consciousness or personal. | The mind is a [[Neurochemistry|neurochemical]] machine it has so many inputs it evolved the subconscious to stop too much noise overwhelming the system. The word Psychedelic means mind-manifesting, i.e. it is taking some of these subconscious inputs and opening it up to the conscious mind. They work like a switch, once present in the system they switch of the inhibitory system and systems become conscious. The effect is that millions of years of heuristics are opened up. Only those which were promoted to the conscious mind were accessible to you, now you can see what is under the hood. However, as we have a limited awareness i.e. processing power it is different to normal consciousness as all of the inputs which had been subdued are now switch on and you are only built to pay attention to one or two things at one time. So the experience is often incapacitating and thus makes us vulnerable. To deal with this the brain tries to find patterns and groups concepts into "icons", metaphorical symbols, which are being seen from a far. Many of these icons can be archetypal of general human consciousness or personal. | ||
== Psychedelic | == Psychedelic Compounds == | ||
[[File:Psychedelic types.png|alt=Much the same.|'''Figure 2'''. The “Classical” Psychedelics are mescaline, LSD, psilocybin, and DMT. Plus the deliriants and dissociatives.|thumb]] | [[File:Psychedelic types.png|alt=Much the same.|'''Figure 2'''. The “Classical” Psychedelics are mescaline, LSD, psilocybin, and DMT. Plus the deliriants and dissociatives.|thumb]] | ||
There are 5 classes of psychedelics based upon their effect and chemistry. | There are 5 classes of psychedelics based upon their effect and chemistry. | ||
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'''Tryptamines''' | '''Tryptamines''' | ||
* Psilocybin / psilocin | * Psilocybin / psilocin found in psilocybin mushrooms | ||
* DMT | * DMT found in accasias and ayahuasca | ||
* 5-MeO-DMT | * 5-MeO-DMT found in toad venom | ||
'''Ergoline''' | '''Ergoline''' | ||
* LSD | * LSD derived from ergot | ||
'''Phenylethylamines''' | '''Phenylethylamines''' | ||
* Mescaline | * Mescaline found in the peyote cactus | ||
* MDMA | * MDMA synthetically made | ||
* 2C-B | * 2C-B synthetically made | ||
'''Deliriants''' | '''Deliriants''' | ||
* Muscimol | * Muscimol found in anamita muscaria | ||
* Ibogane | * Ibogane | ||
'''Dissociatives''' | '''Dissociatives''' | ||
* Ketamine | * Ketamine synthetically made | ||
== Psychedelic Comparison == | |||
Whilst the pharmaceutical industry markets that psychedelics can cure everything from obesity to hair loss, in reality there is little evidence that they can treat any other conditions apart from mental health issues. In regards to mental health, psychedelics as a group have a very similar effect<ref name=":0">Holze, F., Ley, L., Müller, F. ''et al.'' Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects. ''Neuropsychopharmacol.'' 47, 1180–1187 (2022). <nowiki>https://doi.org/10.1038/s41386-022-01297-2</nowiki></ref><ref>Carbonaro TM, Johnson MW, Hurwitz E, Griffiths RR. Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences. Psychopharmacology (Berl). 2018 Feb;235(2):521-534. doi: 10.1007/s00213-017-4769-4. Epub 2017 Nov 7. PMID: 29116367; PMCID: PMC6645364.</ref><ref>Comparison of the Reactions Induced by Psilocybin and LSD-25 in Man, From the National Institute of Mental Health, Addiction Research Center, U. S. Public Health Service, Lexington, Kentucky by HARRIS ISBELL 1959</ref>. | Whilst the pharmaceutical industry markets that psychedelics can cure everything from obesity to hair loss, in reality there is little evidence that they can treat any other conditions apart from mental health issues. In regards to mental health, psychedelics as a group have a very similar effect<ref name=":0">Holze, F., Ley, L., Müller, F. ''et al.'' Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects. ''Neuropsychopharmacol.'' 47, 1180–1187 (2022). <nowiki>https://doi.org/10.1038/s41386-022-01297-2</nowiki></ref><ref>Carbonaro TM, Johnson MW, Hurwitz E, Griffiths RR. Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences. Psychopharmacology (Berl). 2018 Feb;235(2):521-534. doi: 10.1007/s00213-017-4769-4. Epub 2017 Nov 7. PMID: 29116367; PMCID: PMC6645364.</ref><ref>Comparison of the Reactions Induced by Psilocybin and LSD-25 in Man, From the National Institute of Mental Health, Addiction Research Center, U. S. Public Health Service, Lexington, Kentucky by HARRIS ISBELL 1959</ref>. | ||