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== Medical Pacification == | == Medical Pacification == | ||
Evolution is about survival of the fittest. Over time characteristics that | Evolution is about survival of the fittest. Over time characteristics that made us less able in the world were replaced by characteristics which make us more able in the world. With 5.0% of adults in the world suffering from depression<ref>https://www.who.int/news-room/fact-sheets/detail/depression</ref> this poses an evolutionary paradox as to why depression exists. The brain plays crucial roles in promoting survival and reproduction, so the pressures of evolution should have left our brains resistant to such high rates of malfunction. Mental disorders should generally be rare and be getting rarer — ''so why is depression so common and even more growing?'' | ||
Depression is a subjective issue with little to no objective parameters, one can only assume that the disease is partly caused by internal biochemistry and external circumstance. Perhaps higher rates of depression are being caused by external, societal issues? | |||
Psychopharmacology is the study of how specific substances affect how the brain operates. Humans tend to believe that their decision making and sense of self is constant however, it is well documented that specific blood parameters can have a wide range of effects on our decision making. For instance, fluoxetine a common antidepressant can cause people to become more moral<ref>[https://pubmed.ncbi.nlm.nih.gov/20876101/ Serotonin selectively influences moral judgment and behavior through effects on harm aversion.]</ref> or even eating before citing judgement causes judges to become more lenient<ref>https://www.economist.com/science-and-technology/2011/04/14/i-think-its-time-we-broke-for-lunch</ref>. Quetiapine can increase risky decision making<ref>Rock, P. L., Harmer, C. J., McTavish, S. F. B., Goodwin, G. M., & Rogers, R. D. (2011). ''The effects of quetiapine on risky decision-making. International Clinical Psychopharmacology, 26, e141.'' doi:10.1097/01.yic.0000405872.33849.22</ref>. Most of these effects are temporary, i.e. once food has been eaten the judges judgement return to normal, similarly with fluoxetine once it is out of the persons system for 15 days<ref>https://pubmed.ncbi.nlm.nih.gov/8194283/#:~:text=Fluoxetine%20is%20well%20absorbed%20after,has%20a%20nonlinear%20pharmacokinetic%20profile.</ref>. Behavioural changes subside. One class of drugs which shows an incredible ability to change decision making in normal people for the long term are [[psychedelics]]<ref>William McGlothlin , Sidney Cohen & Marcella S. McGlothlin (1970) Long Lasting Effects of LSD on Normals, Journal of Psychoactive Drugs, 3:1, 20-31, DOI: 10.1080/02791072.1970.10471358</ref>. | Psychopharmacology is the study of how specific substances affect how the brain operates. Humans tend to believe that their decision making and sense of self is constant however, it is well documented that specific blood parameters can have a wide range of effects on our decision making. For instance, fluoxetine a common antidepressant can cause people to become more moral<ref>[https://pubmed.ncbi.nlm.nih.gov/20876101/ Serotonin selectively influences moral judgment and behavior through effects on harm aversion.]</ref> or even eating before citing judgement causes judges to become more lenient<ref>https://www.economist.com/science-and-technology/2011/04/14/i-think-its-time-we-broke-for-lunch</ref>. Quetiapine can increase risky decision making<ref>Rock, P. L., Harmer, C. J., McTavish, S. F. B., Goodwin, G. M., & Rogers, R. D. (2011). ''The effects of quetiapine on risky decision-making. International Clinical Psychopharmacology, 26, e141.'' doi:10.1097/01.yic.0000405872.33849.22</ref>. Most of these effects are temporary, i.e. once food has been eaten the judges judgement return to normal, similarly with fluoxetine once it is out of the persons system for 15 days<ref>https://pubmed.ncbi.nlm.nih.gov/8194283/#:~:text=Fluoxetine%20is%20well%20absorbed%20after,has%20a%20nonlinear%20pharmacokinetic%20profile.</ref>. Behavioural changes subside. One class of drugs which shows an incredible ability to change decision making in normal people for the long term are [[psychedelics]]<ref>William McGlothlin , Sidney Cohen & Marcella S. McGlothlin (1970) Long Lasting Effects of LSD on Normals, Journal of Psychoactive Drugs, 3:1, 20-31, DOI: 10.1080/02791072.1970.10471358</ref>. |