SSRI and psychedelics
From BurnZero
Pre-2023 it was a commonly held belief by healthcare practitioners that there was a theoretical interaction between psychedelics and SSRIs that may cause serotonin syndrome, a potentially fatal reaction. However, the serotonin theory of action of antidepressants[1] and psychedelics is now under debate and there is now some empirical data to suggest that there is no interaction[2] or a weak interaction[3].
References
- ↑ “No convincing evidence”. BMJ 2022; 378 doi: https://doi.org/10.1136/bmj.o1808 (Published 20 July 2022) BMJ 2022;378:o1808
- ↑ Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication. Goodwin, G.M., Croal, M., Feifel, D. et al. Neuropsychopharmacol. (2023). https://www.nature.com/articles/s41386-023-01648-7
- ↑ Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910