DMT

N, N-Dimethyltryptamine (DMT) is a psychedelic that induces changes in consciousness which in intensity surpass most other categories of psychoactive drugs. Users consistently experience vivid visual imagery accompanying what is frequently described as a sense of “breaking through” into another world or dimension. These experiences are often deemed profound and have the potential to challenge beliefs about the nature of reality and consciousness. DMT has overwhelmingly rapid, short‐acting effects: when administered intravenously through a bolus injection, subjective and physical effects peak within two minutes of administration and quickly subside thereafter, fully resolving after 20‐30 minutes.

Repeated psychedelic doses of IV bolus DMT injections have been found not to produce any psychological tolerance. This plus the short time‐course of its action makes DMT unique among classic serotonergic psychedelics, and suitable for continuous IV administration.