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[[File:Psychedelic effect.jpg|alt=This figure is from a 2014 study in the Journal of the Royal Society Interface. The image on the left is of a human brain on a placebo, and the image on the right is of a brain on psilocybin.|thumb|'''Figure 1'''. A 2014 study in the ''Journal of the Royal Society Interface''. The image on the left is of a human brain on a placebo, and the image on the right is of a brain on a psychedelic.]] | [[File:Psychedelic effect.jpg|alt=This figure is from a 2014 study in the Journal of the Royal Society Interface. The image on the left is of a human brain on a placebo, and the image on the right is of a brain on psilocybin.|thumb|'''Figure 1'''. A 2014 study in the ''Journal of the Royal Society Interface''. The image on the left is of a human brain on a placebo, and the image on the right is of a brain on a psychedelic.]] | ||
'''Psychedelics are medicinal compounds which affect the functioning of the human mind. | '''Psychedelics are medicinal compounds which affect the functioning of the human mind. Historically, psychedelics have been shrouded in taboo, however with the advent of [[The Psychedelic Renaissance]] this malign is slowly dissipating.''' | ||
Psychedelics are | Psychedelics are not bad or good, they are simply chemicals which induce varying durations and intensities of [[neuroplasticity]] periods. | ||
== Background == | == Background == | ||
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**'''Tobacco Use''' - small study has shown an 80% cessation rate after 6 months which compare to the industry standard of 35%<ref>''An online survey of tobacco smoking cessation associated with naturalistic psychedelic use. Journal of Psychopharmacology, 31(7), 841–850.'' Johnson, M. W., Garcia-Romeu, A., Johnson, P. S., & Griffiths, R. R. (2017). doi:10.1177/0269881116684335 10.1177/0269881116684335</ref>. | **'''Tobacco Use''' - small study has shown an 80% cessation rate after 6 months which compare to the industry standard of 35%<ref>''An online survey of tobacco smoking cessation associated with naturalistic psychedelic use. Journal of Psychopharmacology, 31(7), 841–850.'' Johnson, M. W., Garcia-Romeu, A., Johnson, P. S., & Griffiths, R. R. (2017). doi:10.1177/0269881116684335 10.1177/0269881116684335</ref>. | ||
Numerous studies<ref>'''Psychedelic-Assisted Psychotherapy: A Paradigm Shift in Psychiatric Research and Development.''' Eduardo Ekman Schenberg. Front Pharmacol. 2018; 9: 733. Published online 2018 Jul 5. doi: 10.3389/fphar.2018.00733.</ref> and a systematic review<ref>'''A systematic review of psychedelic-assisted psychotherapy for mental health''': An evaluation of the current wave of research and suggestions for the future. Wheeler, S. W., & Dyer, N. L. (2020). Psychology of Consciousness: Theory, Research, and Practice, 7(3), 279–315. <nowiki>https://doi.org/10.1037/cns0000237</nowiki></ref> have concluded that [[Guided Psychedelic Therapy|guided psychedelic therapy]] can have increased therapeutic effect. | Numerous studies<ref>'''Psychedelic-Assisted Psychotherapy: A Paradigm Shift in Psychiatric Research and Development.''' Eduardo Ekman Schenberg. Front Pharmacol. 2018; 9: 733. Published online 2018 Jul 5. doi: 10.3389/fphar.2018.00733.</ref> and a systematic review<ref>'''A systematic review of psychedelic-assisted psychotherapy for mental health''': An evaluation of the current wave of research and suggestions for the future. Wheeler, S. W., & Dyer, N. L. (2020). Psychology of Consciousness: Theory, Research, and Practice, 7(3), 279–315. <nowiki>https://doi.org/10.1037/cns0000237</nowiki></ref> have concluded that [[Guided Psychedelic Therapy|guided psychedelic therapy]] can have increased therapeutic effect. | ||
== Mechanism of Action == | |||
Psychedelics are [[exogenous neurotransmitters]], that cause neuroplastic, [[Pivotal mental state|pivotal mental states]]. It is thought psychedelics mediate this effect by altering Brain-Derived Neurotrophic Factor (BDNF)<ref>'''Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics''' Cato M. H. de Vos, Natasha L. Mason and Kim P. C. Kuypers* Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands Front. Psychiatry, 10 September 2021 </ref> | |||
== Psychedelic Compounds == | == Psychedelic Compounds == |