Lion's Mane

Lion's Mane (Hericium erinaceus) is rich in β-glucan polysaccharides, which have been found to exhibit anti-cancer^[1], immuno-modulating, hypolipidemic, antioxidant, and neuro-protective properties^[2].

Neuroactivity

Depression

Figure 1. Lion's Mane mechanism of action in depression^[3]

Lion's Mane contains the pharmacologically active compounds hericenones and erinacines which have been shown to stimulate nerve growth factor (NGF) synthesis. There is some evidence to suggest that Lion's Mane can be used in the treatment of depression.^[4]

Cognitive Impairment

There is some evidence to suggest that lions mane can improve cognitive impairment in people above the age of 50^[5]. References

↑ Anti-tumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtou. Mizuno T, Wasa T, Ito H, Suzuki C and Ukai N (1992) Biosci Biotechnol Biochem 56, 347-348. Accessed on 15th Jul 2023 via: https://pubmed.ncbi.nlm.nih.gov/1368310/
↑ Hericium erinaceus: an edible mushroom with medicinal values (2013) Md. Asaduzzaman Khan,Mousumi Tania, Rui Liu, Mohammad Mijanur Rahman Antioxidant Gene Taxonomy (biology). Journal Of Complementary And Integrative Medicine. Accessed on 15th January 2023 via https://oa.mg/work/10.1515/jcim-2013-0001?
↑ Therapeutic Potential of Hericium erinaceus for Depressive Disorder by Pit Shan Chong ,Man-Lung Fung , Kah Hui Wong *ORCID and Lee Wei Lim. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. Int. J. Mol. Sci. 2020, Accessed 15th July 2023 via: https://www.mdpi.com/1422-0067/21/1/163
↑ Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake (2010). Mayumi Nagano, Kuniyoshi Shimizu, J-Stage, Biomedical Research. Accessed on 15th July 2023 via: https://doi.org/10.2220/biomedres.31.231
↑ Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A Double-blind Placebo-controlled Clinical Trial. Phytother. Res. 23, 367–372 (2009) Published online 10 October 2008 in Wiley InterScienc. Accessed on 15 Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/18844328/

[1] Anti-tumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtou. Mizuno T, Wasa T, Ito H, Suzuki C and Ukai N (1992) Biosci Biotechnol Biochem 56, 347-348. Accessed on 15th Jul 2023 via: https://pubmed.ncbi.nlm.nih.gov/1368310/

[2] Hericium erinaceus: an edible mushroom with medicinal values (2013) Md. Asaduzzaman Khan,Mousumi Tania, Rui Liu, Mohammad Mijanur Rahman Antioxidant Gene Taxonomy (biology). Journal Of Complementary And Integrative Medicine. Accessed on 15th January 2023 via https://oa.mg/work/10.1515/jcim-2013-0001?

[3] Therapeutic Potential of Hericium erinaceus for Depressive Disorder by Pit Shan Chong ,Man-Lung Fung , Kah Hui Wong *ORCID and Lee Wei Lim. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. Int. J. Mol. Sci. 2020, Accessed 15th July 2023 via: https://www.mdpi.com/1422-0067/21/1/163

[4] Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake (2010). Mayumi Nagano, Kuniyoshi Shimizu, J-Stage, Biomedical Research. Accessed on 15th July 2023 via: https://doi.org/10.2220/biomedres.31.231

[5] Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A Double-blind Placebo-controlled Clinical Trial. Phytother. Res. 23, 367–372 (2009) Published online 10 October 2008 in Wiley InterScienc. Accessed on 15 Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/18844328/

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Neuroactivity

Depression

Cognitive Impairment

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