Nitrous Oxide

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Since the 19th century, nitrous oxide, also referred to as laughing gas, has been used in medicine as an anaesthetic to lessen pain. However, in smaller doses, it can cause mind-altering experiences, similar to those brought on by the psychedelic drugs ketamine and LSD. These effects include feelings of bliss, spirituality, and a sense of being outside of one's body.

Compare the effects of nitrous oxide, ketamine, and LSD on functional connectivity:
Figure 1. Comparative effects of nitrous oxide, ketamine, and LSD on functional connectivity:

Recent clinical studies suggest that nitrous oxide may be effective for treatment-resistant depression[1].

References

  1. Nitrous Oxide: an emerging novel treatment for treatment-resistant depression. Journal of the Neurological Sciences Volume 434, Published 15 March 2022. Accessed 14 May 2023 via https://pubmed.ncbi.nlm.nih.gov/34953347/

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