Depression

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Depression is a form of mental illness which is characterised by a negative cognitive bias resulting in depressed mood, loss of interest in activities, or cognitive impairment[1]. The causative factor(s) of the disease may be external via the environment (exogenous) or internal via a neurochemical imbalance (endogenous) (see Figure 1).

Endogenous depression vs exogenous depression
Figure 1. Exogenous causes of depression are often missed my psychometric analysis.

Diagnosis

Diagnosis of depression was traditionally performed by a psychiatrist, however due to an overdue amount of human error[2][3] [4]in the modern day this has shifted to psychometric tests.

Treatment

Depression may be a natural reaction to the environment. To treat the disease, external factors should be eliminated first, then endogenous issues should be explored. The main points to initially address are:

  1. Healthy diet - supplementation of Vitamin D3 and Omega 3, ↓ alcohol consumption.
  2. Sunlight - running outside as below can bolster Vitamin D3 as above.
  3. Exercise - 3+ times a week get heart rate above resting and maintain, walk in nature[5].
  4. Sleeping well - by exposing yourself to sunlight you can reset your Circadian Rhythm whilst exercise will help you sleep.
  5. Reducing overstimulation - anti rumination, reduce caffeine intake do more mindfulness and meditation.
  6. Talking - self therapy, counselling, increase social contact.

Relapse

People who have recovered from an episode of depression (whether spontaneously or following the provision of treatment) are at an increased risk of becoming depressed again in the future. This risk can be as high as 60% for people who have experienced one episode, 70% in those who have had two episodes, and 90% in those who have had three previous episodes (American Psychiatric Association, 2000). Psychological therapies delivered following recovery from depression, including CBT, MBCT, and IPT, may reduce risk of relapse after one year by 22%[6].

References

  1. The association between overweight/obesity and poor cognitive function is mediated by inflammation in patients with major depressive disorder. Xiaofeng Lan, Chengyu Wang, Weicheng Li, Ziyuan Chao, Guohui Lao, Kai Wu, Guixiang Li, Yuping Ning, Yanling Zhou, Journal of Affective Disorders, Volume 313, 2022, Pages 118-125,https://doi.org/10.1016/j.jad.2022.06.073.
  2. Rates of Detection of Mood and Anxiety Disorders in Primary Care: A Descriptive, Cross-Sectional Study Monica Vermani, PsyD, Madalyn Marcus, MA. Prim Care Companion CNS Disord. 2011; 13(2): PCC.10m01013. doi: 10.4088/PCC.10m01013. Accessed on 30th November 2022 via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184591/
  3. Analysis of Misdiagnosis of Bipolar Disorder in An Outpatient Setting. Shen H, Zhang L, Xu C, Zhu J, Chen M, Fang Y. Shanghai Arch Psychiatry. 2018 Apr 25;30(2):93-101. doi: 10.11919/j.issn.1002-0829.217080. PMID: 29736129; PMCID: PMC5936046. Accessed on 30 November 2022 via: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936046/
  4. Beyond Misdiagnosis, Misunderstanding and Mistrust: Relevance of the Historical Perspective in the Medical and Mental Health Treatment of People of Color. Derek H. Suite, MD, MS; Robert La Bril, MDiv; Annelle Primm, MD, MPH; and Phyllis Harrison-Ross, MD. Accessed on 30 November 2022 via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574307/pdf/jnma00207-0025.pdf
  5. The effects of walking in nature on negative and positive affect in adult psychiatric outpatients with major depressive disorder: Kia Watkins-Martin, Despina Bolanis, Stéphane Richard-Devantoy, Marie-Hélène Pennestri, Catherine Malboeuf-Hurtubise, Frederick Philippe, Julie Guindon, Jean-Philippe Gouin, Isabelle Ouellet-Morin, Marie-Claude Geoffroy, A randomized-controlled study, Journal of Affective Disorders, Volume 318, 2022,Pages 291-298, ISSN 0165-0327, https://doi.org/10.1016/j.jad.2022.08.121.
  6. Can non-pharmacological interventions prevent relapse in adults who have recovered from depression? A systematic review and meta-analysis of randomised controlled trials. Clinical Psychology Review. Volume 39, July 2015, Pages 58-70

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