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Amanita muscaria

Amanita muscaria

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Amanita muscaria (also known as fly agaric or fly amanita Figure 1) is a psychoactive mushroom that grows widely in the northern hemisphere. The mushroom is a large white-gilled, white-spotted, usually red mushroom that is one of the most recognizable and widely encountered in popular culture 🍄. The mushroom is arguably[1] the Soma-plant in Vedic religion[2] as it is noted for its Lilliputian hallucinatory properties, which derive from its primary psychoactive constituents ibotenic acid and muscimol[3].

Amanita as a psychoactive
Figure 1. Amanita Muscaria aka: Fly Agaric, Soma, Toadstool
Amanita muscaria lookalikes.
Figure 2. Amanita muscaria lookalikes.

Although the fresh mushroom is classified as poisonous[4], reports of human deaths resulting from its ingestion are extremely rare[5]. Furthermore, there are a multitude of recorded cases of low dose ingestion without issue[6]. The key to its safety is differentiation from the Destroying Angel and the Death Cap, parboiling—which weakens its toxicity and breaks down the mushroom's psychoactive substances and careful dosage[7]. To this day, the dried mushroom is used as a medicinal ingredient, and as a substitute for alcohol in parts of Russia as a narcotic by the Koryak people[8].

Differentiation

One of the major dangers of amanita muscaria is misidentifying it as a different species of mushroom. Several other mushrooms in the genus amanita are toxic and cause 90% of all fatal mushroom poisonings see figure 2. One such mushroom, the amanita phalloides, better known as the death cap, contains α-amanitin and β-Amanitin, both of which are extremely potent RNA polymerase II and RNA polymerase III inhibitors which damage virtually every tissue in the body. As the name suggests, the amanita muscaria contains the chemical muscarine, a muscarinic acetylcholine agonist which is known to cause seizures; however, the mushroom contains very low amounts that are highly unlikely to pose any significant harm.

Identification

Found in forests from July to October, this Amanita has a symbiotic relationship with various trees, and is most often found under pines, spruces, and birches. The problem with the identification of the Amanita (and this is a general mushroom rule) is that rain may alter its appearance considerably by washing away its patches or draining its vibrant red to a paler shade. With these more superficial characteristics erased, it can easily be mistaken for an innocuous or edible look-alike. Beware of look-alikes!

Ingestion

There is a long history of edibility of the prepared mushroom in Japan[9]. Traditional knowledge highlighted that in its raw state this mushroom is toxic and inebriating and therefore did not ingest it as such. They consumed it only after certain preparations: "Dried, soaked in brine for 12-13 weeks, rinsed in successive washings until the water became clear. They came out alabaster white and indeed are translucent like alabaster. Prepared thus for savouring during the long winter evenings, they are delicious, excellent as hors d'oeuvres"

Pharmacology

 
Figure 3. Lilliputian hallucinations

The active ingredients of the Amanita muscaria are ibotenic acid, muscimol, and muscarine the highest concentration of which is in the yellow tissue of the cap immediately below the skin[10]. The first two ingredients act on the nervous system as GABAA agonists within thirty minutes to two hours after ingestion, causing dizziness, lack of coordination, delirium, spasms, and muscular cramps. These symptoms are temporary and subside within four to twenty-four hours. There is some evidence to suggest that the reported lilliputian hallucinations (see Figure 3) mimic Z-drug side effects[11][12][13][14][15].

Toxicity

Ibotenic acid is known to be a neurotoxin, acting via the NMDA receptor and metabotropic glutamate receptor. Ibotenic acid can be converted to muscimol via decarboxylation. This can be performed using a combination of heat and acid-catalysis with the potential for adding decarboxylasing enzymes such as milk / lactobacillus derivatives which contain glutamate decarboxylase.

Preparation

In light of the potential toxicity it has been shown to best reduce nausea and vomiting by making a tea from dried amanita muscaria. The preparation techniques have been shown "no significant variation in the likelihood of experiencing psychoactive effects[16]", however they do vary in the amount of side effects produced. The most effective preparation method is described in a patent which uses a laboratory and a reactant comprising of glutamate decarboxylase (potentially soured milk)[17].

Dose

A medium-size fresh carpophore with a cap diameter of 10-15 cm weighs about 60-70 g. According to literature reports[2], Siberian mushroom eaters used for moderate effects 1-4 dried mushrooms and 5-10 was considered immoderate use. For dosing, start with a small amount such as 1/4 or 1 teaspoon while you are awake, and see how it affects you. Each new separate day while you are awake, increase the amount by a little until you then have the dose or dose range you want to experiment with. If your liquid is extra potent you can experiment with this same liquid at expected dosing for several weeks (or all year if used infrequently). Effects will typically begin anywhere from 15 to 120 minutes after consumption.

Small-dose effects can include mild to moderate relaxing euphoria and warm body sensations, increased ability to meditate, as well as light muscle spasms and a somewhat energetic feeling, soon followed by a sense of peace and sleepiness. Sleep can be renewing, with intense, vivid dreams that are difficult to recall in detail upon waking. It can also significantly reduce the number of times one wakes up during sleep.

Contraindications

It may be harmful to combine Amanita muscaria constituents with other GABAergic depressants such as alcohol, benzodiazepines or barbiturates. Amanita muscaria mushrooms are not known to be addictive or dependence-forming, and reports even show that desire to redose goes down with usage, though there is no research on this topic.

Effect

Lilliputian hallucinations concern hallucinated human, animal or fantasy entities of minute size. They have been reported anecdotally for millennia however, in the 1960s while the number of medical publications on lilliputian hallucinations had dwindled, young people became fascinated with records of ancient shamanic traditions and expressed a longing to encounter the sentient, discarnate beings described after the use of psychedelics[18].

References

  1. ↑ Soma and "Amanita muscaria" Author(s): John Brough Source: Bulletin of the School of Oriental and African Studies, University of London, Vol. 34, No. 2 (1971), pp. 331-362 Published by: Cambridge University Press on behalf of School of Oriental and African Studies Stable URL: http://www.jstor.org/stable/612695
  2. ↑ 2.0 2.1 Soma: Divine Mushroom of Immortality by R. Gordon Wasson by Sungazer Press (first published January 1st 1968)
  3. ↑ Hallucinogenic Species in Amanita Muscaria. Determination of Muscimol and Ibotenic Acid by Ion Interaction HPLC M. C. Gennaro a , D. Giacosa a , E. Gioannini a & S. Angelino a a Università di Torino Dipartimento di Chimica Analitica Via P. Giuria , 5 10125, Torino, Italy Published online: 23 Sep 2006.
  4. ↑ Michelot, D., & Melendez-Howell, L. M. (2003). Amanita muscaria: chemistry, biology, toxicology, and ethnomycology. Mycological Research, 107(2), 131–146. doi:10.1017/s0953756203007305
  5. ↑ Fly agaric (Amanita muscaria) poisoning, case report and review Leszek Satora*, Dorota Pach, Beata Butryn, Piotr Hydzik, Barbara Balicka-S´lusarczyk Department of Clinical Toxicology, Poison Information Center, Collegium Medicum, Jagiellonian University, Os. Złotej Jesieni 1, 31-826 Krako´w, Poland Received 12 November 2004; accepted 10 January 2005 Available online 14 April 2005
  6. ↑ Buck, R. W. (1963). Toxicity of Amanita muscaria. JAMA: The Journal of the American Medical Association, 185(8), 663. doi:10.1001/jama.1963.03060080059020
  7. ↑ Neuropharmacological Investigations on Muscimol, a Psychotropic Drug Extracted from Amanita Muscaria* A. Sco~TI DE CA~OHS, F. LIPPA/~INI and V. G. LONGO Laboratori di Chimica Terapeutica, Istituto Superiore di Sanit&, Roma, Italia Received March 10, 1969
  8. ↑ Russian Use of Amanita muscaria: A Footnote to Wasson's Soma Author(s): Ethel Dunn Source: Current Anthropology, Vol. 14, No. 4 (Oct., 1973), pp. 488-492 Published by: The University of Chicago Press on behalf of Wenner-Gren Foundation for Anthropological Research Stable URL: http://www.jstor.org/stable/2740856 . Accessed: 16/02/2015 19:02
  9. ↑ "Amanita muscaria": The Gorgeous Mushroom Author(s): Christal Whelan Source: Asian Folklore Studies, Vol. 53, No. 1 (1994), pp. 163-167 Published by: Nanzan University Stable URL: http://www.jstor.org/stable/1178564 . Accessed: 18/06/2014 00:23
  10. ↑ United Nations, Amanita muscaria : present understanding of its chemistry Accessed on 18th Jun 2022 viahttps://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1970-01-01_4_page005.html
  11. ↑ Tsai MJ, Huang YB, Wu PC. A novel clinical pattern of visual hallucination after zolpidem use. J Toxicol Clin Toxicol. 2003;41:869–72.
  12. ↑ Coleman DE, Ota K. Hallucinations with zolpidem and fluoxetine in an impaired driver. J Forensic Sci. 2004;49:392–3.
  13. ↑ Kito S, Koga Y. Visual hallucinations and amnesia associated with zolpidem triggered by fluvoxamine: A possible interaction. Int Psychogeriatr. 2006;18:749–51.
  14. ↑ Elko CJ, Burgess JL, Robertson WO. Zolpidem-associated hallucinations and serotonin reuptake inhibition: A possible interaction. J Toxicol Clin Toxicol. 1998;36:195–203.
  15. ↑ Zolpidem-induced Hallucinations: A Brief Case Report from the Indian Subcontinent. Gurvinder Pal Singh and Neeraj Loona. Indian J Psychol Med. 2013 Apr-Jun; 35(2): 212–213. doi: 10.4103/0253-7176.116260
  16. ↑ Revisiting Wasson's Soma: Exploring the Effects of Preparation on the Chemistry of Amanita Muscaria Kevin Feeney a a Department of Anthropology , Washington State University , Pullman, WA Published online: 20 Sep 2011.
  17. ↑ Method for producing muscimol and/or reducing ibotenic acid from amanita tissue.https://patents.google.com/patent/US20140004084A1/en
  18. ↑ The Invisible Landscape: Mind, Hallucinogens, and the I Ching, Terence Mckenna, published in 1993, ISBN 0062506358
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