Trip Terminator

Kentanserin and olanzapine^[1] have been found to stop psychedelic trips.

Olanzapine is an atypical antipsychotic. Kentanserin a research chemical and antagonist of 5-HT2A binds to the main psychedelic receptor but does not activate it. A recent study showed that giving participants kentanserin 1 hour after giving them LSD reduced the duration of LSD's subjective effects from around 8.5 hours to 3.5 hours^[2]. In theory, kentanserin might have use for reducing or terminating a psychedelic experience.

References

↑ Olanzapine as the ideal “trip terminator”? Giuseppe Valeriani, Ornella Corazza, Francesco Saverio Bersani. First published: 28 July 2015 https://doi.org/10.1002/hup.2431. Accessed via: https://onlinelibrary.wiley.com/doi/10.1002/hup.2431
↑ Ketanserin reverses the acute response to LSD in a randomized, double-blind, placebo-controlled, crossover study in healthy subjects. Anna M Becker, Aaron Klaiber, Friederike Holze, Ioanna Istampoulouoglou, Urs Duthaler, Nimmy Varghese, Anne Eckert, Matthias E Liechti. International Journal of Neuropsychopharmacology, 2022;, pyac075, https://doi.org/10.1093/ijnp/pyac075

[1] Olanzapine as the ideal “trip terminator”? Giuseppe Valeriani, Ornella Corazza, Francesco Saverio Bersani. First published: 28 July 2015 https://doi.org/10.1002/hup.2431. Accessed via: https://onlinelibrary.wiley.com/doi/10.1002/hup.2431

[2] Ketanserin reverses the acute response to LSD in a randomized, double-blind, placebo-controlled, crossover study in healthy subjects. Anna M Becker, Aaron Klaiber, Friederike Holze, Ioanna Istampoulouoglou, Urs Duthaler, Nimmy Varghese, Anne Eckert, Matthias E Liechti. International Journal of Neuropsychopharmacology, 2022;, pyac075, https://doi.org/10.1093/ijnp/pyac075

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