SSRI and psychedelics

Theoretically, when SSRIs such as fluoxetine are taken at the same time as a psychedelic, serotonin syndrome, a potentially fatal reaction can occur may occur. However, although this reaction is theoretically possible there is no confirming empirical data. Recently, the serotonin theory of depression has been cast into doubt by large studies, further disproving this theory.

However, SSRI and SNRIs appear to weaken psilocybin drug effects relative to a non-serotonergic antidepressant. This dampening effect may last as long as 3 months following antidepressant discontinuation.

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