Microdosing: Difference between revisions
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'''A microdose is a dose of [[Psychedelics|psychedelic]] medicine which is sub perceptual in nature, meaning taking the dose does not cause any change in perception / consciousness. A microdose is imprecisely defined as different people have different sensitivities to psychedelics, however it is generally accepted that it is approximately one tenth of a psychedelic dose, repeated every 3-5 days.''' | '''A microdose is a dose of [[Psychedelics|psychedelic]] medicine which is sub perceptual in nature, meaning taking the dose does not cause any change in perception / consciousness. A microdose is imprecisely defined as different people have different sensitivities to psychedelics, however it is generally accepted that it is approximately one tenth of a psychedelic dose, repeated every 3-5 days.''' | ||
In the vast majority of human studies [[microdosing]] has been shown to have no effect and even in some have shown negative effects such as neuroticism or even the potential to cause valvular heart disease. However, an animal study has found that 0.25g [[psilocybin]] (equivalent human dose) increases resilience to stress, lowers compulsive actions, and strengthens cortical connections to the paraventricular thalamic nucleus<ref>'''Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats''' Kat F. Kiilerich, Joe Lorenz. https://www.nature.com/articles/s41380-023-02280-z</ref>. | In the vast majority of human studies [[microdosing]] has been shown to have no effect and even in some have shown negative effects such as neuroticism or even the potential to cause valvular heart disease. However, an animal study has found that 0.25g [[psilocybin]] (equivalent human dose) increases resilience to stress, lowers compulsive actions, and strengthens cortical connections to the paraventricular thalamic nucleus<ref>'''Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats''' Kat F. Kiilerich, Joe Lorenz. https://www.nature.com/articles/s41380-023-02280-z</ref>. Some recent studies have shown that LSD microdosing was found to increase neural complexity<ref>Murray, C.H., Frohlich, J., Haggarty, C.J. ''et al.'' Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine. ''Neuropsychopharmacol.'' (2024). <nowiki>https://doi.org/10.1038/s41386-024-01809-2</nowiki></ref> and have an antidepressant effect<ref>'''Molla, H., et al. (2024). "Greater subjective effects of a low dose of LSD in participants with depressed mood."''' Neuropsychopharmacology 49(5): 774-781. https://www.nature.com/articles/s41386-023-01772-4</ref>. | ||
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Revision as of 23:33, 2 May 2024
A microdose is a dose of psychedelic medicine which is sub perceptual in nature, meaning taking the dose does not cause any change in perception / consciousness. A microdose is imprecisely defined as different people have different sensitivities to psychedelics, however it is generally accepted that it is approximately one tenth of a psychedelic dose, repeated every 3-5 days.
In the vast majority of human studies microdosing has been shown to have no effect and even in some have shown negative effects such as neuroticism or even the potential to cause valvular heart disease. However, an animal study has found that 0.25g psilocybin (equivalent human dose) increases resilience to stress, lowers compulsive actions, and strengthens cortical connections to the paraventricular thalamic nucleus[1]. Some recent studies have shown that LSD microdosing was found to increase neural complexity[2] and have an antidepressant effect[3].
Reference
- ↑ Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats Kat F. Kiilerich, Joe Lorenz. https://www.nature.com/articles/s41380-023-02280-z
- ↑ Murray, C.H., Frohlich, J., Haggarty, C.J. et al. Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine. Neuropsychopharmacol. (2024). https://doi.org/10.1038/s41386-024-01809-2
- ↑ Molla, H., et al. (2024). "Greater subjective effects of a low dose of LSD in participants with depressed mood." Neuropsychopharmacology 49(5): 774-781. https://www.nature.com/articles/s41386-023-01772-4