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Repeated psychedelic doses of IV bolus DMT injections have been found not to produce any psychological tolerance. This plus the short time‐course of its action makes DMT unique among classic serotonergic psychedelics, and suitable for continuous IV administration. | Repeated psychedelic doses of IV bolus DMT injections have been found not to produce any psychological tolerance. This plus the short time‐course of its action makes DMT unique among classic serotonergic psychedelics, and suitable for continuous IV administration. | ||
DMT is metabolized by MAO-A and that blocking this enzyme with harmala alkaloids results in either greater intensity and/or duration of DMT’s action. | |||
It is thought like with other [[psychedelics]] its main action comes from 5HT2A agonism, however it has been shown that DMT has a unique action on Sigma 1 receptors<ref>'''N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain'''. Szabó a, Viktória É. Varga a. Neuropharmacology. Volume 192, 1 July 2021, 108612. <nowiki>https://www.sciencedirect.com/science/article/pii/S0028390821001660</nowiki></ref>. | It is thought like with other [[psychedelics]] its main action comes from 5HT2A agonism, however it has been shown that DMT has a unique action on Sigma 1 receptors<ref>'''N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain'''. Szabó a, Viktória É. Varga a. Neuropharmacology. Volume 192, 1 July 2021, 108612. <nowiki>https://www.sciencedirect.com/science/article/pii/S0028390821001660</nowiki></ref>. | ||