SSRI and psychedelics: Difference between revisions

Revision as of 01:53, 21 July 2022

It is thought that if psychedelics are used with SSRIs such as fluoxetine this may lead to serotonin syndrome and a decrease in subjective psychedelic effects. However, this is theoretical and there is no empirical data on the interaction between psychedelics and antidepressants.

References

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-Many of the subjective and biological effects of classical psychedelics are blocked after administering 5HT2AR antagonists such as ketanserin.<ref>Preller KH, Herdener M, Pokorny T, Planzer A, Kraehenmann R, Stämpfli P, et al. The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation. Curr Biol. 2017 Feb;27(3):451–7.</ref><ref>Ly C, Greb AC, Cameron LP, Wong JM, Barragan EV, Wilson PC, et al. Psychedelics Promote Structural and Functional Neural Plasticity. Cell Rep. 2018 Jun 12;23(11):3170–82.</ref> This leads to the potential for serotonin syndrome and a decrease in subjective psychedelic effects. However, there is no empirical data on the interaction between psychedelics and antidepressants, and whether this raises the risk of [[serotonin]] syndrome.
+It is thought that if psychedelics are used with SSRIs such as fluoxetine this may lead to serotonin syndrome and a decrease in subjective psychedelic effects. However, this is theoretical and there is no empirical data on the interaction between psychedelics and antidepressants.
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Revision as of 01:53, 21 July 2022

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