MDMA: Difference between revisions

Line 1:

[[File:MDMA.jpg|alt=Ecstasy|thumb|'''Figure 1.''' MDMA in pill form, aka Ecstasy]]

'''MDMA, commonly known as ecstasy or Molly, is a synthetic drug that induces both amphetamine-like stimulation and mild [[hallucinations]].''' ~~The~~ mechanism ~~of action involves a decrease in activity within the limbic system~~, ~~a group of structures responsible for emotional responses. Furthermore, there is a reduction in communication between the medial temporal lobe~~ and ~~the medial prefrontal cortex, which play roles in emotional control. Collectively, these effects are contrary to the patterns observed~~ in ~~individuals experiencing anxiety.~~

'''MDMA, commonly known as ecstasy or Molly, is a synthetic drug that induces both amphetamine-like stimulation and mild [[hallucinations]].''' MDMA has been shown to enhance fear memory extinction, modulate fear memory reconsolidation (possibly through an oxytocin-dependent mechanism), and bolster social behavior in animal models

== Clinical Dosage ==

Line 24:

10. Final integration session.

== Mechanism of Action ==

The mechanism of action involves a decrease in activity within the limbic system, a group of structures responsible for emotional responses. Furthermore, there is a reduction in communication between the medial temporal lobe and the medial prefrontal cortex, which play roles in emotional control. Collectively, these effects are contrary to the patterns observed in individuals experiencing anxiety.<ref>'''3,4-Methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats.''' Hake, H. S. et al. ''Physiol. Behav.'' 199, 343–350 (2019). http://scholar.google.com/scholar_lookup?&title=3%2C4-Methylenedioxymethamphetamine%20%28MDMA%29%20impairs%20the%20extinction%20and%20reconsolidation%20of%20fear%20memory%20in%20rats&journal=Physiol.%20Behav.&doi=10.1016%2Fj.physbeh.2018.12.007&volume=199&pages=343-350&publication_year=2019&author=Hake%2CHS</ref><ref>'''Oxytocin-dependent reopening of a social reward learning critical period with MDMA.''' Nardou, R. et al. ''Nature'' 569, 116–120 (2019). https://doi.org/10.1038%2Fs41586-019-1075-9</ref>

== Effects ==

@@ Line 1: / Line 1: @@
 [[File:MDMA.jpg|alt=Ecstasy|thumb|'''Figure 1.''' MDMA in pill form, aka Ecstasy]]
-'''MDMA, commonly known as ecstasy or Molly, is a synthetic drug that induces both amphetamine-like stimulation and mild [[hallucinations]].''' The mechanism of action involves a decrease in activity within the limbic system, a group of structures responsible for emotional responses. Furthermore, there is a reduction in communication between the medial temporal lobe and the medial prefrontal cortex, which play roles in emotional control. Collectively, these effects are contrary to the patterns observed in individuals experiencing anxiety.
+'''MDMA, commonly known as ecstasy or Molly, is a synthetic drug that induces both amphetamine-like stimulation and mild [[hallucinations]].''' MDMA has been shown to enhance fear memory extinction, modulate fear memory reconsolidation (possibly through an oxytocin-dependent mechanism), and bolster social behavior in animal models
 == Clinical Dosage ==
@@ Line 24: / Line 24: @@
 . Final integration session.
+== Mechanism of Action ==
+The mechanism of action involves a decrease in activity within the limbic system, a group of structures responsible for emotional responses. Furthermore, there is a reduction in communication between the medial temporal lobe and the medial prefrontal cortex, which play roles in emotional control. Collectively, these effects are contrary to the patterns observed in individuals experiencing anxiety.<ref>'''3,4-Methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats.''' Hake, H. S. et al. ''Physiol. Behav.'' 199, 343–350 (2019). http://scholar.google.com/scholar_lookup?&title=3%2C4-Methylenedioxymethamphetamine%20%28MDMA%29%20impairs%20the%20extinction%20and%20reconsolidation%20of%20fear%20memory%20in%20rats&journal=Physiol.%20Behav.&doi=10.1016%2Fj.physbeh.2018.12.007&volume=199&pages=343-350&publication_year=2019&author=Hake%2CHS</ref><ref>'''Oxytocin-dependent reopening of a social reward learning critical period with MDMA.''' Nardou, R. et al.  ''Nature'' 569, 116–120 (2019). https://doi.org/10.1038%2Fs41586-019-1075-9</ref>
 == Effects ==

Share your opinion