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MDMA: Difference between revisions
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=== Short Term === | === Short Term === | ||
[[File:MDMA Time Effect Curve.png|alt=The dynamic of an MDMA trip is not linear, it takes effect at 30-45 minutes and peaks at 2 hours.|thumb|'''Figure 1'''. MDMA Time-Effect Curve]] | [[File:MDMA Time Effect Curve.png|alt=The dynamic of an MDMA trip is not linear, it takes effect at 30-45 minutes and peaks at 2 hours.|thumb|'''Figure 1'''. MDMA Time-Effect Curve]] | ||
When taken orally, MDMA starts to take effect in about 30 to 45 minutes, with its impact lasting between three to six hours. The experience is often gentler compared to [[psychedelics]] and is characterised by feelings of enthusiasm, empathy and trust. | When taken orally, MDMA starts to take effect in about 30 to 45 minutes, with its impact lasting between three to six hours. The experience is often gentler compared to [[psychedelics]] and is characterised by feelings of enthusiasm, empathy and trust. MDMA is often described as affiliative which is the opposite to dissociative which is and effect often associated with medicines such as [[ketamine]]. | ||
=== Long Term === | === Long Term === | ||
MDMA aids in enhancing understanding and management of emotions and coping mechanisms, primarily by augmenting [[Fear Memory Extinction|fear memory extinction]] and rewiring association to trauma leading to decreased amygdala activation. This results in a changed perspective and better processing of traumatic memories. Furthermore, MDMA can modulate fear memory reconsolidation, potentially through effects on oxytocin or activation of serotonin 5HT1B receptors, and improve social behaviors, as observed in animal studies. | MDMA aids in enhancing understanding and management of emotions and coping mechanisms, primarily by augmenting [[Fear Memory Extinction|fear memory extinction]] and rewiring association to trauma leading to decreased amygdala activation. This results in a changed perspective and better processing of traumatic memories. Furthermore, MDMA can modulate fear memory reconsolidation, potentially through effects on oxytocin or activation of serotonin 5HT1B receptors, and improve social behaviors, as observed in animal studies. | ||