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SSRI and psychedelics: Difference between revisions

SSRI and psychedelics: Difference between revisions

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Theoretically, when SSRIs such as fluoxetine are taken at the same time as a psychedelic, [[serotonin]] syndrome, a potentially fatal reaction can occur may occur. However, although this reaction is theoretically possible there is no confirming empirical data. Recently, the serotonin theory of depression has been cast into doubt by large studies<ref>'''“No convincing evidence”'''. BMJ 2022; 378 doi: <nowiki>https://doi.org/10.1136/bmj.o1808</nowiki> (Published 20 July 2022) BMJ 2022;378:o1808</ref>, further disproving this theory.
'''Pre-2023 it was a commonly held belief by healthcare practitioners that there was a theoretical interaction between psychedelics and SSRIs that may cause [[serotonin]] syndrome, a potentially fatal reaction.''' However, the serotonin theory of action of antidepressants<ref>'''“No convincing evidence”'''. BMJ 2022; 378 doi: <nowiki>https://doi.org/10.1136/bmj.o1808</nowiki> (Published 20 July 2022) BMJ 2022;378:o1808</ref> and psychedelics is now under debate and there is now some empirical data to suggest that there is no interaction<ref>'''Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication.''' Goodwin, G.M., Croal, M., Feifel, D. ''et al. Neuropsychopharmacol.'' (2023). https://www.nature.com/articles/s41386-023-01648-7</ref> or a weak interaction<ref>'''Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use'''. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910</ref>.<hr>
 
However, SSRI and SNRIs appear to weaken [[psilocybin]] drug effects relative to a non-serotonergic antidepressant. This dampening effect may last as long as 3 months following antidepressant discontinuation<ref>'''Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use'''. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910</ref>.
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'''References'''
'''References'''

Revision as of 02:51, 15 July 2023

Pre-2023 it was a commonly held belief by healthcare practitioners that there was a theoretical interaction between psychedelics and SSRIs that may cause serotonin syndrome, a potentially fatal reaction. However, the serotonin theory of action of antidepressants[1] and psychedelics is now under debate and there is now some empirical data to suggest that there is no interaction[2] or a weak interaction[3].

References

  1. ↑ “No convincing evidence”. BMJ 2022; 378 doi: https://doi.org/10.1136/bmj.o1808 (Published 20 July 2022) BMJ 2022;378:o1808
  2. ↑ Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication. Goodwin, G.M., Croal, M., Feifel, D. et al. Neuropsychopharmacol. (2023). https://www.nature.com/articles/s41386-023-01648-7
  3. ↑ Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910
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