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Lion's Mane: Difference between revisions

Lion's Mane: Difference between revisions

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=== Neuroactivity ===
=== Neuroactivity ===
Lion's Mane contains the pharmacologically active compounds hericenones and erinacines which have been shown to stimulate human nerve growth factor (NGF) synthesis<ref>'''Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1''', Human Astrocytoma Cells Koichiro MORI, a,c Yutaro OBARA, a,b Mitsuru HIROTA. Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan. Accessed on 15th Jul 2023 via <nowiki>https://pubmed.ncbi.nlm.nih.gov/18758067/</nowiki></ref>.


==== Depression ====
==== Depression ====
[[File:Lions mane for depression.jpg|alt=Lions mane for depression|thumb|'''Figure 1'''. Lion's Mane mechanism of action in depression<ref>'''Therapeutic Potential of Hericium erinaceus for Depressive Disorder''' by Pit Shan Chong ,Man-Lung Fung , Kah Hui Wong *ORCID and Lee Wei Lim. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. Int. J. Mol. Sci. 2020, Accessed 15th July 2023 via: <nowiki>https://www.mdpi.com/1422-0067/21/1/163</nowiki></ref>]]
[[File:Lions mane for depression.jpg|alt=Lions mane for depression|thumb|'''Figure 1'''. Lion's Mane mechanism of action in depression<ref>'''Therapeutic Potential of Hericium erinaceus for Depressive Disorder''' by Pit Shan Chong ,Man-Lung Fung , Kah Hui Wong *ORCID and Lee Wei Lim. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. Int. J. Mol. Sci. 2020, Accessed 15th July 2023 via: <nowiki>https://www.mdpi.com/1422-0067/21/1/163</nowiki></ref>]]
Lion's Mane contains the pharmacologically active compounds hericenones and erinacines which have been shown to stimulate nerve growth factor (NGF) synthesis. There is some evidence to suggest that Lion's Mane can be used in the treatment of depression.<ref>'''Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake''' (2010). Mayumi Nagano, Kuniyoshi Shimizu, J-Stage, Biomedical Research. Accessed on 15th July 2023 via: https://doi.org/10.2220/biomedres.31.231</ref>
There is some evidence to suggest that Lion's Mane can be used in the treatment of depression.<ref>'''Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake''' (2010). Mayumi Nagano, Kuniyoshi Shimizu, J-Stage, Biomedical Research. Accessed on 15th July 2023 via: https://doi.org/10.2220/biomedres.31.231</ref>


==== Cognitive Impairment ====
==== Cognitive Impairment ====
There is some evidence to suggest that lions mane can improve cognitive impairment in people above the age of 50<ref>'''Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A n=30 Double-blind Placebo-controlled Clinical Trial.''' Phytother. Res. 23, 367–372 (2009) Published online 10 October 2008 in Wiley InterScienc. Accessed on 15 Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/18844328/</ref>.
There is some evidence to suggest that lions mane can improve cognitive impairment in people above the age of 50<ref>'''Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A n=30 Double-blind Placebo-controlled Clinical Trial.''' Phytother. Res. 23, 367–372 (2009) Published online 10 October 2008 in Wiley InterScienc. Accessed on 15 Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/18844328/</ref>.


==== Neuroregenerative ====
==== Neuroprotective and Neuroregenerative ====
Has been found to have some neuroregenrative effects in rat studies<ref>'''Hericium erinaceusa medicinal mushroom, activates peripheral nerve regeneration.''' Wong, Kah-Hui; Kanagasabapathy, Gowri; Naidu, Murali; David, Pamela; Sabaratnam, Vikineswary. Chinese Journal of Integrative Medicine. Accessed on 15 Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/25159861/</ref>.
Has been found to have some neuroprotective<ref>'''Enhancement of the neuroprotective activity of Hericium erinaceus mycelium co-cultivated with Allium sativum extract'''. Kim, Myong Ki; Choi, Woon Yong; Lee, Hyeon Yong. 10.3109/13813455.2014.974618. Archives of Physiology and Biochemistry. Accessed on 15th Jul 2023 via: https://pubmed.ncbi.nlm.nih.gov/25354984/</ref> and neuroregenrative<ref>'''Hericium erinaceusa medicinal mushroom, activates peripheral nerve regeneration.''' Wong, Kah-Hui; Kanagasabapathy, Gowri; Naidu, Murali; David, Pamela; Sabaratnam, Vikineswary. Chinese Journal of Integrative Medicine. Accessed on 15 Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/25159861/</ref> effects in rat studies.
 
=== Stamets Stack ===
There is some evidence to suggest that by combining [[psilocybin]], lions mane and niacin this can increase the improvement of cognitive function.<ref>'''Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls''' (Published: 30 June 2022). Joseph M. Rootman, Maggie Kiraga, Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Kim P. C. Kuypers & Zach Walsh. Accessed on 18 Jul 2023 via: https://www.nature.com/articles/s41598-022-14512-3</ref>


'''References'''
'''References'''
<references />
<references />

Latest revision as of 23:29, 17 July 2023

Lion's Mane (Hericium erinaceus) is rich in β-glucan polysaccharides, which have been found to exhibit anti-cancer[1], immuno-modulating, hypolipidemic, antioxidant, and neuro-protective properties[2].

Neuroactivity

Lion's Mane contains the pharmacologically active compounds hericenones and erinacines which have been shown to stimulate human nerve growth factor (NGF) synthesis[3].

Depression

Lions mane for depression
Figure 1. Lion's Mane mechanism of action in depression[4]

There is some evidence to suggest that Lion's Mane can be used in the treatment of depression.[5]

Cognitive Impairment

There is some evidence to suggest that lions mane can improve cognitive impairment in people above the age of 50[6].

Neuroprotective and Neuroregenerative

Has been found to have some neuroprotective[7] and neuroregenrative[8] effects in rat studies.

Stamets Stack

There is some evidence to suggest that by combining psilocybin, lions mane and niacin this can increase the improvement of cognitive function.[9]

References

  1. ↑ Anti-tumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtou. Mizuno T, Wasa T, Ito H, Suzuki C and Ukai N (1992) Biosci Biotechnol Biochem 56, 347-348. Accessed on 15th Jul 2023 via: https://pubmed.ncbi.nlm.nih.gov/1368310/
  2. ↑ Hericium erinaceus: an edible mushroom with medicinal values (2013) Md. Asaduzzaman Khan,Mousumi Tania, Rui Liu, Mohammad Mijanur Rahman Antioxidant Gene Taxonomy (biology). Journal Of Complementary And Integrative Medicine. Accessed on 15th January 2023 via https://oa.mg/work/10.1515/jcim-2013-0001?
  3. ↑ Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1, Human Astrocytoma Cells Koichiro MORI, a,c Yutaro OBARA, a,b Mitsuru HIROTA. Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan. Accessed on 15th Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/18758067/
  4. ↑ Therapeutic Potential of Hericium erinaceus for Depressive Disorder by Pit Shan Chong ,Man-Lung Fung , Kah Hui Wong *ORCID and Lee Wei Lim. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. Int. J. Mol. Sci. 2020, Accessed 15th July 2023 via: https://www.mdpi.com/1422-0067/21/1/163
  5. ↑ Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake (2010). Mayumi Nagano, Kuniyoshi Shimizu, J-Stage, Biomedical Research. Accessed on 15th July 2023 via: https://doi.org/10.2220/biomedres.31.231
  6. ↑ Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A n=30 Double-blind Placebo-controlled Clinical Trial. Phytother. Res. 23, 367–372 (2009) Published online 10 October 2008 in Wiley InterScienc. Accessed on 15 Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/18844328/
  7. ↑ Enhancement of the neuroprotective activity of Hericium erinaceus mycelium co-cultivated with Allium sativum extract. Kim, Myong Ki; Choi, Woon Yong; Lee, Hyeon Yong. 10.3109/13813455.2014.974618. Archives of Physiology and Biochemistry. Accessed on 15th Jul 2023 via: https://pubmed.ncbi.nlm.nih.gov/25354984/
  8. ↑ Hericium erinaceusa medicinal mushroom, activates peripheral nerve regeneration. Wong, Kah-Hui; Kanagasabapathy, Gowri; Naidu, Murali; David, Pamela; Sabaratnam, Vikineswary. Chinese Journal of Integrative Medicine. Accessed on 15 Jul 2023 via https://pubmed.ncbi.nlm.nih.gov/25159861/
  9. ↑ Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls (Published: 30 June 2022). Joseph M. Rootman, Maggie Kiraga, Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Kim P. C. Kuypers & Zach Walsh. Accessed on 18 Jul 2023 via: https://www.nature.com/articles/s41598-022-14512-3
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