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Setting: Difference between revisions

Setting: Difference between revisions

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'''Setting refers to a concept created by Timothy Leary<ref>'''Constructing drug effects: A history of set and setting'''. Drug Science, Policy and Law. Ido Hartogsohn First Published January 1, 2017 <nowiki>https://doi.org/10.1177/2050324516683325</nowiki></ref> which addresses the physical location as to where the [[psychedelics]] are experienced.''' This is opposed to [[priming]] which refers to the pre administration mental state. While the concept of priming and setting was born out of psychedelic research it has also been proven useful for researchers who have studied the effects of various stimulants, depressants, and antipsychotics such as alcohol, heroin, methylphenidate (Ritalin), methamphetamine<ref>Dwyer, R, Moore, D (2013) Enacting multiple methamphetamines: the ontological politics of public discourse and consumer accounts of a drug and its effects. The International Journal on Drug Policy 24(3): 203–211.</ref>, cocaine, and crack cocaine<ref>Zinberg, NE (1984) Drug, Set, and Setting: The Basis for Controlled Intoxicant Use, 1st ed. New Haven, CT: Yale University Press.</ref>. Essentially, where you take the medicine can affect the action of the medicine, via [[psychosomatics]].
'''Setting, a concept developed by Timothy Leary<ref>'''Constructing drug effects: A history of set and setting'''. Drug Science, Policy and Law. Ido Hartogsohn First Published January 1, 2017 <nowiki>https://doi.org/10.1177/2050324516683325</nowiki></ref>, refers to the physical environment in which [[psychedelics]] are consumed.''' This is distinct from [[priming]], which relates to the mental state before drug administration. While initially applied in psychedelic research, these concepts have also proven useful in studying the effects of substances like alcohol, heroin, Ritalin, methamphetamine<ref>Dwyer, R, Moore, D (2013) Enacting multiple methamphetamines: the ontological politics of public discourse and consumer accounts of a drug and its effects. The International Journal on Drug Policy 24(3): 203–211.</ref>, cocaine, and crack cocaine<ref>Zinberg, NE (1984) Drug, Set, and Setting: The Basis for Controlled Intoxicant Use, 1st ed. New Haven, CT: Yale University Press.</ref>. The key idea behind setting is that the location where a drug is taken can influence its effects, possibly through [[Psychosomatics|psychosomatic]] mechanisms.


== Best Practice setting ==
== Best Practice setting ==
Extensive medical research has been conducted to establish what are the best conditions for a [[Psychedelic Experience|psychedelic experience]]. Highlighted areas to address include<ref>'''Effects of Setting on Psychedelic Experiences, Therapies, and Outcomes''': A Rapid Scoping Review of the Literature. Chapter in Current Topics in Behavioral Neurosciences · February 2022 DOI: 10.1007/7854_2021_298 </ref>:
Extensive medical research has been conducted to establish what are the best conditions for a [[Psychedelic Experience|psychedelic experience]]. Highlighted areas to address include<ref>'''Effects of Setting on Psychedelic Experiences, Therapies, and Outcomes''': A Rapid Scoping Review of the Literature. Chapter in Current Topics in Behavioral Neurosciences · February 2022 DOI: 10.1007/7854_2021_298 </ref>:


* '''Music''' - induces relaxation and stress reduction<ref>'''Set and Setting: A Randomized Study of Different Musical Genres in Supporting Psychedelic Therapy'''. ACS Pharmacol. Transl. Sci. 2021, 4, 2, 472–478, Publication Date:December 29, 2020, <nowiki>https://doi.org/10.1021/acsptsci.0c00187</nowiki></ref><ref>'''Music and soulmaking toward a new theory of music therapy.''' Lanham, MD: Scarecrow Press. Crowe, B. (2004).  de Araujo, D., Ribeiro, S., Cecchi, G. A., Carvalho, F. M., Sanchez, T. A., Pinto, J. P., et al. (2012). Seeing with the eyes shut: neural basis of enhanced imagery following ayahuasca ingestion. Hum. Brain Mapp. 33 (11), 2550–2560. doi:10.1002/hbm.21381</ref> whilst giving a time dependent medium for emotional expression<ref>'''“The neuroscience of emotion and music,” in Communicative musicality: exploring the basis of human companionship.''' Panksepp, J., and Trevarthen, C. (2009). Editors S. Malloch, and C. Trevarthen (Oxford, United Kingdom: Oxford University Press, 105–146.</ref>.
* [[File:Effects of music on psychedelic.png|alt=external stimulation and brain|thumb|'''Figure 1'''. By increasing external stimulation there is a narrower effect on the brain.]]'''[[Music and Psychedelic Experiences|Music]]''' - induces relaxation and stress reduction<ref>'''Set and Setting: A Randomized Study of Different Musical Genres in Supporting Psychedelic Therapy'''. ACS Pharmacol. Transl. Sci. 2021, 4, 2, 472–478, Publication Date:December 29, 2020, <nowiki>https://doi.org/10.1021/acsptsci.0c00187</nowiki></ref><ref>'''Music and soulmaking toward a new theory of music therapy.''' Lanham, MD: Scarecrow Press. Crowe, B. (2004).  de Araujo, D., Ribeiro, S., Cecchi, G. A., Carvalho, F. M., Sanchez, T. A., Pinto, J. P., et al. (2012). Seeing with the eyes shut: neural basis of enhanced imagery following ayahuasca ingestion. Hum. Brain Mapp. 33 (11), 2550–2560. doi:10.1002/hbm.21381</ref> whilst giving a time dependent medium for emotional expression<ref>'''“The neuroscience of emotion and music,” in Communicative musicality: exploring the basis of human companionship.''' Panksepp, J., and Trevarthen, C. (2009). Editors S. Malloch, and C. Trevarthen (Oxford, United Kingdom: Oxford University Press, 105–146.</ref>. However, one study has shown that listening to music decreases entropy and can potentially reduce the overall therapeutic effect (see '''Figure 1''')<ref>'''Effects of External Stimulation on Psychedelic State Neurodynamics.''' Mediano, Pedro A., Fernando E. Rosas, Christopher Timmermann, Leor Roseman, David J. Nutt, Amanda Feilding, Mendel Kaelen, et al. 2024. ''ACS Chemical Neuroscience'', January. doi:10.1021/acschemneuro.3c00289. https://pubs.acs.org/doi/10.1021/acschemneuro.3c00289</ref>.
*'''Singing''' - singing, whistling or drumming elicits oxytocin production a neurohormone enhancing calming and social bonding<ref>'''What’s missing from the scientific study of religion?''' Dunbar, R. (2017). ''Religion, Brain Behav.'' 7 (4), 349–353. doi:10.1080/2153599X.2016.1249927</ref>.
* '''Lighting''' - most prefer psychedelic sessions at night and some it strange to start a ceremony at midday<ref>The Evolved Psychology of Psychedelic Set and Setting: Inferences Regarding the Roles of Shamanism and Entheogenic Ecopsychology. Front. Pharmacol., Published 23 February 2021, Sec. Ethnopharmacology. <nowiki>https://doi.org/10.3389/fphar.2021.619890</nowiki></ref>. It has been found that using a blindfold to reduce ambient light increases the intensity of the psychedelic experience<ref>https://pubs.acs.org/doi/10.1021/acschemneuro.3c00289#</ref>.
* '''Lighting''' - most prefer psychedelic sessions at night and would feel it strange to start a ceremony at midday<ref>The Evolved Psychology of Psychedelic Set and Setting: Inferences Regarding the Roles of Shamanism and Entheogenic Ecopsychology. Front. Pharmacol., Published 23 February 2021, Sec. Ethnopharmacology. <nowiki>https://doi.org/10.3389/fphar.2021.619890</nowiki></ref>.
*'''Physical attributes of the medicine''' - much like placebo, size, colour, smell; all contribute to the effect<ref>'''Set and setting, psychedelics and the placebo response''': An extra-pharmacological perspective on psychopharmacology. Ido Hartogsohn, Journal of Psychopharmacology
*'''Physical attributes of the medicine''' - much like placebo size, colour, smell all contribute to the effect<ref>'''Set and setting, psychedelics and the placebo response''': An extra-pharmacological perspective on psychopharmacology. Ido Hartogsohn, Journal of Psychopharmacology


2016. DOI: 10.1177/0269881116677852.</ref>.
2016. DOI: 10.1177/0269881116677852.</ref>.
*'''Fasting''' - to ensure pharmacokinetic stability, patients should fast for an average of 2-4 h (except water)<ref>'''Therapeutic use of psilocybin: Practical considerations for dosing and administration.''' MacCallum CA, Lo LA, Pistawka CA, Deol JK.  Front Psychiatry. 2022 Dec 1;13:1040217. doi: 10.3389/fpsyt.2022.1040217. PMID: 36532184; PMCID: PMC9751063. Accessed via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751063/</ref>.
*'''Singing''' - singing, whistling or drumming elicits oxytocin production a neurohormone enhancing calming and social bonding<ref>'''What’s missing from the scientific study of religion?''' Dunbar, R. (2017). ''Religion, Brain Behav.'' 7 (4), 349–353. doi:10.1080/2153599X.2016.1249927</ref>.


==== Pre ====
==== Pre ====
To reiterate, to get on the correct trajectory and enhance the therapeutic effect [[priming]] is of the utmost importance: "Have an objective, don't just go in to get fucked because you will. A great goal is to ''let go of anger and sadness and to be reminded of beauty and happiness''" - Sting
To reiterate, to get on the correct trajectory and enhance the therapeutic effect of psychedelic medicine, [[priming]] is of the utmost importance: "Have an objective, don't just go in to get fucked because you will. A great goal is to ''let go of anger and sadness and to be reminded of beauty and happiness''" - Sting


==== During ====
==== During ====
[[File:Letting go during psychedelics.png|alt=Letting go during psychedelics|thumb|'''Figure 1'''. How to let go during a psychedelic experience.]]
[[File:Letting go during psychedelics.png|alt=Letting go during psychedelics|thumb|'''Figure 2'''. How to let go during a psychedelic experience.]]
Remember to let go, the [[Psychedelic Experience|psychedelic experience]] will temporarily dissolve the neural pathways which make up how you perceive the world around you. However, it is easy to forget this and feel as if YOU are physically dissolving into the world around you. Occasionally, time distorts however remember that it will be over. No matter what, you aren't going to die, you aren't going to go mad and the effects are not permanent.
Remember to let go, the [[Psychedelic Experience|psychedelic experience]] will temporarily dissolve the neural pathways which make up how you perceive the world around you. However, it is easy to forget this and feel as if YOU are physically dissolving into the world around you (see '''Figure 2'''). Occasionally, time distorts however, remember that it will be over. No matter what, you aren't going to die, you aren't going to go mad and the effects are not permanent.


==== Integration ====
==== Integration ====
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=== Setting Modulation ===
=== Setting Modulation ===
Once the basics as above have been covered, it is possible to experiment on an individual basis, below is a list of Psychedelic Visualisation Modulators which can be used to explore the psychedelic effect on the visual field.
Once the basics as above have been covered, it is possible to modulate you environment to see how the mind is effected. An simple place to start is to use a Psychedelic Visualisation Modulator, which can be used to explore the psychedelic effect on the visual field.


====== Psychedelic Visualisation Modulators ======
====== Psychedelic Visualisation Modulators ======
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====== Psychedelic Psychical Modulators ======
To enhance healing during a [[psilocybin]] or [[MDMA]] experiences, focus on releasing trauma stored in the body rather than overthinking problems.
# About 30-60 minutes into the trip, when things may feel chaotic, stay calm and begin a self-massage technique.
# Once you feel the psilocybin's effects, remove your shirt and start massaging your upper body.
# Use your hands to apply different strokes or pressures across your shoulders, arms, chest, neck, and belly. Follow what feels good or right—whether gentle caressing or firmer pressure.
# As you massage, old memories, emotions, or traumas may arise. This indicates that you're releasing negative energy from your body. Trauma is stored in your muscles, not your mind, so physical release through massage is key.
# Continue until you feel you've released tension from all parts of your body. You might end up fully naked, addressing the areas that feel burdened by trapped emotions.


==== After ====
==== After ====

Latest revision as of 10:13, 4 October 2024

Setting, a concept developed by Timothy Leary[1], refers to the physical environment in which psychedelics are consumed. This is distinct from priming, which relates to the mental state before drug administration. While initially applied in psychedelic research, these concepts have also proven useful in studying the effects of substances like alcohol, heroin, Ritalin, methamphetamine[2], cocaine, and crack cocaine[3]. The key idea behind setting is that the location where a drug is taken can influence its effects, possibly through psychosomatic mechanisms.

Best Practice setting

Extensive medical research has been conducted to establish what are the best conditions for a psychedelic experience. Highlighted areas to address include[4]:

  • external stimulation and brain
    Figure 1. By increasing external stimulation there is a narrower effect on the brain.
    Music - induces relaxation and stress reduction[5][6] whilst giving a time dependent medium for emotional expression[7]. However, one study has shown that listening to music decreases entropy and can potentially reduce the overall therapeutic effect (see Figure 1)[8].
  • Lighting - most prefer psychedelic sessions at night and some it strange to start a ceremony at midday[9]. It has been found that using a blindfold to reduce ambient light increases the intensity of the psychedelic experience[10].
  • Physical attributes of the medicine - much like placebo, size, colour, smell; all contribute to the effect[11].
  • Fasting - to ensure pharmacokinetic stability, patients should fast for an average of 2-4 h (except water)[12].
  • Singing - singing, whistling or drumming elicits oxytocin production a neurohormone enhancing calming and social bonding[13].

Pre

To reiterate, to get on the correct trajectory and enhance the therapeutic effect of psychedelic medicine, priming is of the utmost importance: "Have an objective, don't just go in to get fucked because you will. A great goal is to let go of anger and sadness and to be reminded of beauty and happiness" - Sting

During

Letting go during psychedelics
Figure 2. How to let go during a psychedelic experience.

Remember to let go, the psychedelic experience will temporarily dissolve the neural pathways which make up how you perceive the world around you. However, it is easy to forget this and feel as if YOU are physically dissolving into the world around you (see Figure 2). Occasionally, time distorts however, remember that it will be over. No matter what, you aren't going to die, you aren't going to go mad and the effects are not permanent.

Integration

Integration is the time immediately after the psychedelic experience, it is seen as a closing window of opportunity to integrate new thought patterns into the software of the brain. By employing various technique during the integration period specific positive effects of psychedelic use can be maintained.

Setting Modulation

Once the basics as above have been covered, it is possible to modulate you environment to see how the mind is effected. An simple place to start is to use a Psychedelic Visualisation Modulator, which can be used to explore the psychedelic effect on the visual field.

Psychedelic Visualisation Modulators
Link Summary Settings Interactive
Hop Along A never ending orbits visualizer. Use keys and mouse to increase speed and angle Yes Yes
Strobe Stare at the middle for 30 seconds for to experience an optical illusion No No
Weavesilk Generate art Yes Yes
Balls demo Colorful balls that follow your mouse (Enable fullscreen for best effect) Yes Yes
Chromoscope Explore the Milky Way in various wavelengths Yes Yes
Particle Dream Particle visualization with many options Yes Yes
Cosmic Symbolism Never ending cosmic zooming experience (click and drag for speed) No Yes
Draw A 3D Mandala Draw a mandala with different colors in 3d Yes Yes
Mr Doob Harmony Make art by sketching with different materials and colors (many more triptoys at the top of the page) Yes Yes
Fluids Colorful physics demonstration of fluid Yes Yes
Water physics Physics demonstration. Move around, drag the ball, ripple the water. Yes Yes
Arkadia Never ending psychedelic forest No No
Puddle Interact with paint-like soundwaves No Yes
A Way To Go Draw lines and walk through a forest while creating music No Yes
Soft Murmur Create your own mix of background noise Yes Yes
MyNoise.net Ambient noise generator with a variety of themes from rain to black holes to busy cafe to kitten purrs. Yes No
Psychedelic Psychical Modulators

To enhance healing during a psilocybin or MDMA experiences, focus on releasing trauma stored in the body rather than overthinking problems.

  1. About 30-60 minutes into the trip, when things may feel chaotic, stay calm and begin a self-massage technique.
  2. Once you feel the psilocybin's effects, remove your shirt and start massaging your upper body.
  3. Use your hands to apply different strokes or pressures across your shoulders, arms, chest, neck, and belly. Follow what feels good or right—whether gentle caressing or firmer pressure.
  4. As you massage, old memories, emotions, or traumas may arise. This indicates that you're releasing negative energy from your body. Trauma is stored in your muscles, not your mind, so physical release through massage is key.
  5. Continue until you feel you've released tension from all parts of your body. You might end up fully naked, addressing the areas that feel burdened by trapped emotions.

After

This is the most important part of the psychedelic experience, afterwards you remain in a neuroplastic state and have the ability to integrate what was learnt during the psychedelic experience.

References

  1. ↑ Constructing drug effects: A history of set and setting. Drug Science, Policy and Law. Ido Hartogsohn First Published January 1, 2017 https://doi.org/10.1177/2050324516683325
  2. ↑ Dwyer, R, Moore, D (2013) Enacting multiple methamphetamines: the ontological politics of public discourse and consumer accounts of a drug and its effects. The International Journal on Drug Policy 24(3): 203–211.
  3. ↑ Zinberg, NE (1984) Drug, Set, and Setting: The Basis for Controlled Intoxicant Use, 1st ed. New Haven, CT: Yale University Press.
  4. ↑ Effects of Setting on Psychedelic Experiences, Therapies, and Outcomes: A Rapid Scoping Review of the Literature. Chapter in Current Topics in Behavioral Neurosciences · February 2022 DOI: 10.1007/7854_2021_298
  5. ↑ Set and Setting: A Randomized Study of Different Musical Genres in Supporting Psychedelic Therapy. ACS Pharmacol. Transl. Sci. 2021, 4, 2, 472–478, Publication Date:December 29, 2020, https://doi.org/10.1021/acsptsci.0c00187
  6. ↑ Music and soulmaking toward a new theory of music therapy. Lanham, MD: Scarecrow Press. Crowe, B. (2004). de Araujo, D., Ribeiro, S., Cecchi, G. A., Carvalho, F. M., Sanchez, T. A., Pinto, J. P., et al. (2012). Seeing with the eyes shut: neural basis of enhanced imagery following ayahuasca ingestion. Hum. Brain Mapp. 33 (11), 2550–2560. doi:10.1002/hbm.21381
  7. ↑ “The neuroscience of emotion and music,” in Communicative musicality: exploring the basis of human companionship. Panksepp, J., and Trevarthen, C. (2009). Editors S. Malloch, and C. Trevarthen (Oxford, United Kingdom: Oxford University Press, 105–146.
  8. ↑ Effects of External Stimulation on Psychedelic State Neurodynamics. Mediano, Pedro A., Fernando E. Rosas, Christopher Timmermann, Leor Roseman, David J. Nutt, Amanda Feilding, Mendel Kaelen, et al. 2024. ACS Chemical Neuroscience, January. doi:10.1021/acschemneuro.3c00289. https://pubs.acs.org/doi/10.1021/acschemneuro.3c00289
  9. ↑ The Evolved Psychology of Psychedelic Set and Setting: Inferences Regarding the Roles of Shamanism and Entheogenic Ecopsychology. Front. Pharmacol., Published 23 February 2021, Sec. Ethnopharmacology. https://doi.org/10.3389/fphar.2021.619890
  10. ↑ https://pubs.acs.org/doi/10.1021/acschemneuro.3c00289#
  11. ↑ Set and setting, psychedelics and the placebo response: An extra-pharmacological perspective on psychopharmacology. Ido Hartogsohn, Journal of Psychopharmacology 2016. DOI: 10.1177/0269881116677852.
  12. ↑ Therapeutic use of psilocybin: Practical considerations for dosing and administration. MacCallum CA, Lo LA, Pistawka CA, Deol JK.  Front Psychiatry. 2022 Dec 1;13:1040217. doi: 10.3389/fpsyt.2022.1040217. PMID: 36532184; PMCID: PMC9751063. Accessed via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751063/
  13. ↑ What’s missing from the scientific study of religion? Dunbar, R. (2017). Religion, Brain Behav. 7 (4), 349–353. doi:10.1080/2153599X.2016.1249927
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