SSRI and psychedelics: Difference between revisions
From BurnZero
mNo edit summary |
mNo edit summary |
||
| Line 1: | Line 1: | ||
Theoretically, when SSRIs such as fluoxetine are taken at the same time as a psychedelic, [[serotonin]] syndrome, a potentially fatal reaction can occur may occur. However, although this reaction is theoretically possible there is no confirming empirical data. Recently, the serotonin theory of depression has been cast into doubt by large studies<ref>'''“No convincing evidence”'''. BMJ 2022; 378 doi: <nowiki>https://doi.org/10.1136/bmj.o1808</nowiki> (Published 20 July 2022) BMJ 2022;378:o1808</ref>, further disproving this theory. | |||
However, SSRI and SNRIs appear to weaken [[psilocybin]] drug effects relative to a non-serotonergic antidepressant. This dampening effect may last as long as 3 months following antidepressant discontinuation<ref>'''Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use'''. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910</ref>. | |||
<hr> | <hr> | ||
'''References''' | '''References''' | ||
Revision as of 07:54, 14 June 2023
Theoretically, when SSRIs such as fluoxetine are taken at the same time as a psychedelic, serotonin syndrome, a potentially fatal reaction can occur may occur. However, although this reaction is theoretically possible there is no confirming empirical data. Recently, the serotonin theory of depression has been cast into doubt by large studies[1], further disproving this theory.
However, SSRI and SNRIs appear to weaken psilocybin drug effects relative to a non-serotonergic antidepressant. This dampening effect may last as long as 3 months following antidepressant discontinuation[2].
References
- ↑ “No convincing evidence”. BMJ 2022; 378 doi: https://doi.org/10.1136/bmj.o1808 (Published 20 July 2022) BMJ 2022;378:o1808
- ↑ Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use. Natalie Gukasyan. Accessed on 14 Jun 2023 via : https://journals.sagepub.com/doi/10.1177/02698811231179910