Microdosing
A microdose is a dose of psychedelic medicine which is sub perceptual in nature, meaning taking the dose does not cause any change in perception / consciousness. A microdose is imprecisely defined as different people have different sensitivities to psychedelics, however it is generally accepted that it is approximately one tenth of a psychedelic dose, repeated every 3-5 days.
In the vast majority of human studies microdosing has been shown to have no effect and even in some have shown negative effects such as neuroticism or even the potential to cause valvular heart disease. However, an animal study has found that 0.25g psilocybin (equivalent human dose) increases resilience to stress, lowers compulsive actions, and strengthens cortical connections to the paraventricular thalamic nucleus[1].
Reference
- ↑ Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats Kat F. Kiilerich, Joe Lorenz. https://www.nature.com/articles/s41380-023-02280-z